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The IMGT/HLA Database

  • Protocol
Immunoinformatics

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 409))

Summary

The human leukocyte antigen (HLA) complex is located within the 6p21.3 region on the short arm of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and include many highly polymorphic HLA genes. The naming of new HLA genes and allele sequences and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. The IMGT/HLA Database acts as the repository for these sequences and is recognized as the primary source of up-to-date and accurate HLA sequences. The IMGT/HLA website provides a number of tools for accessing the database: these include allele reports, sequence alignments, and sequence similarity searches. The website is updated every 3 months with all the new and confirmatory sequences submitted to the WHO Nomenclature Committee. Submission of HLA sequences to the committee is possible through the tools provided by the IMGT/HLA Database.

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Acknowledgments

We would like to thank Matthew Waller and Sylvie Fail for their curation of the database. We would like to acknowledge the support of the following organizations: Abbott Laboratories Inc., the American Society for Histocompatibility and Immunogenetics (ASHI), the Anthony Nolan Bone Marrow Trust (ANBMT), Biotest, Dynal, the European Federation for Immunogenetics (EFI), Genovision, LabCorp, Histogenetics, Innogenetics, the NMDP, the Marrow Foundation, and One Lambda Inc. In particular, we thank Ram Ray at the NMDP for his support and effort in co-ordinating funding for this project. Initial support for the IMGT/HLA Database project was from the ICRF (now Cancer Research UK) and an EU Biotech grant (BIO4CT960037).

Author information

Authors and Affiliations

  1. Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, UK

    James Robinson

  2. Department of Haematology, Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, UK

    Steven G.E. Marsh

Authors
  1. James Robinson
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  2. Steven G.E. Marsh
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Editor information

Editors and Affiliations

  1. The Jenner Institute, University of Oxford, Berkshire, UK

    Darren R. Flower

Appendix: Access and Contact

Appendix: Access and Contact

IMGT/HLA Homepage: http://www.ebi.ac.uk/imgt/hla/

IMGT/HLA FTP Site: ftp://ftp.ebi.ac.uk/pub/databases/imgt/mhc/hla/

Contact: hladb@ebi.ac.uk

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© 2007 Humana Press Inc.

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Cite this protocol

Robinson, J., Marsh, S.G. (2007). The IMGT/HLA Database. In: Flower, D.R. (eds) Immunoinformatics. Methods in Molecular Biology™, vol 409. Humana Press. https://doi.org/10.1007/978-1-60327-118-9_3

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  • DOI: https://doi.org/10.1007/978-1-60327-118-9_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-699-3

  • Online ISBN: 978-1-60327-118-9

  • eBook Packages: Springer Protocols

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