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References

  1. Poletti V, Costabel U. Bronchiolar disorders: classification and diagnostic approach. Semin Respir Crit Care Med 2003;24:457–464.

    Article  PubMed  Google Scholar 

  2. Couture C, Colby T V. Histopathology of bronchiolar disorders. Semin Respir Crit Care Med 2003;24:489–498.

    Article  PubMed  Google Scholar 

  3. Wright JL, Cagle P, Churg A, Colby T V, Myers J. Diseases of the small airways. Am Rev Respir Dis 1992;146:240–262.

    CAS  PubMed  Google Scholar 

  4. Ryu JH. Classification and approach to bronchiolar diseases. Curr Opin Pulm Med 2006;12:145–151.

    Article  PubMed  Google Scholar 

  5. Ryu JH, Myers JL, Swensen SJ. Bronchiolar disorders. Am J Respir Crit Care Med 2003; 168:1277–1292.

    Article  PubMed  Google Scholar 

  6. White ES, Tazelaar HD, Lynch JP, 3rd. Bronchiolar complications of connective tissue diseases. Semin Respir Crit Care Med 2003;24:543–566.

    Article  PubMed  Google Scholar 

  7. Boswell RT, McCunney RJ. Bronchiolitis obliterans from exposure to incinerator fly ash. J Occup Environ Med 1995;37:850–855.

    Article  CAS  PubMed  Google Scholar 

  8. Belperio JA, Lake K, Tazelaar H, Keane MP, Strieter RM, Lynch JP, 3rd. Bronchiolitis oblit-erans syndrome complicating lung or heart-lung transplantation. Semin Respir Crit Care Med 2003;24:499–530.

    Article  PubMed  Google Scholar 

  9. Kotloff RM, Ahya VN, Crawford SW. Pulmonary complications of solid organ and hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2004;170:22–48.

    Article  PubMed  Google Scholar 

  10. Mahadeva R, Walsh G, Flower CD, Shneerson JM. Clinical and radiological characteristics of lung disease in inflammatory bowel disease. Eur Respir J 2000;15:41–48.

    Article  CAS  PubMed  Google Scholar 

  11. Paganin F, Seneterre E, Chanez P, Daurés JP, Bruel JM, Michel FB, Bousquet J. Computed tomography of the lungs in asthma: influence of disease severity and etiology. Am J Respir Crit Care Med 1996;153:110–114.

    CAS  PubMed  Google Scholar 

  12. Reittner P, Muller Nl, Heyneman L, Johkoh T, Park JS, Lee KS, Honda O, Tomiyama N. Mycoplasma pneumoniae pneumonia: radiographic and high-resolution ct features in 28 patients. AJR Am J Roentgenol 2000;174:37–41.

    CAS  PubMed  Google Scholar 

  13. Alasaly K, Muller N, Ostrow DN, Champion P, FitzGerald JM. Cryptogenic organizing pneumonia. A report of 25 cases and a review of the literature. Medicine (Baltimore) 1995;74: 201–211.

    Article  CAS  Google Scholar 

  14. Cordier JF. Organising pneumonia. Thorax 2000;55:318–328.

    Article  CAS  PubMed  Google Scholar 

  15. Schlesinger C, Koss MN. The organizing pneumonias: an update and review. Curr Opin Pulm Med 2005;11:422–430.

    Article  PubMed  Google Scholar 

  16. Schlesinger C, Veeraraghavan S, Koss MN. Constrictive (obliterative) bronchiolitis. Curr Opin Pulm Med 1998;4:288–293.

    Article  CAS  PubMed  Google Scholar 

  17. Myers JL, Colby T V. Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis. Clin Chest Med 1993;14: 611–622.

    CAS  PubMed  Google Scholar 

  18. Pipavath SJ, Lynch DA, Cool C, Brown KK, Newell JD. Radiologic and pathologic features of bronchiolitis. AJR Am J Roentgenol 2005;185:354–363.

    PubMed  Google Scholar 

  19. King TE, Jr. Miscellaneous causes of bronchiolitis: inhalational, infectious, drug-induced, and idiopathic. Semin Respir Crit Care Med 2003;24:567–576.

    Article  PubMed  Google Scholar 

  20. Wells AU, Nicholson AG, Hansell DM, du Bois RM. Respiratory bronchiolitis-associated interstitial lung disease. Semin Respir Crit Care Med 2003;24:585–594.

    Article  PubMed  Google Scholar 

  21. Fraig M, Shreesha U, Savici D, Katzenstein AL. Respiratory bronchiolitis: a clinicopatho-logic study in current smokers, ex-smokers, and never-smokers. Am J Surg Pathol 2002;26:647–653.

    Article  PubMed  Google Scholar 

  22. Moon J, du Bois RM, Colby T V, Hansell DM, Nicholson AG. Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease. Thorax 1999;54:1009–1014.

    Article  CAS  PubMed  Google Scholar 

  23. Churg A, Wright JL. Bronchiolitis caused by occupational and ambient atmospheric particles. Semin Respir Crit Care Med 2003;24:577–584.

    Article  PubMed  Google Scholar 

  24. Howling SJ, Hansell DM, Wells AU, Nicholson AG, Flint JD, Muller NL. Follicular bron-chiolitis: thin-section CT and histologic findings. Radiology 1999;212:637–642.

    CAS  PubMed  Google Scholar 

  25. Verschakelen JA. Imaging of the small airways. Semin Respir Crit Care Med 2003;24: 473–488.

    Article  PubMed  Google Scholar 

  26. Kudoh S, Keicho N. Diffuse panbronchiolitis. Semin Respir Crit Care Med 2003;24: 607–618.

    Article  PubMed  Google Scholar 

  27. Fitzgerald JE, King TE, Jr., Lynch DA, Tuder RM, Schwarz MI. Diffuse panbronchiolitis in the United States. Am J Respir Crit Care Med 1996;154:497–503.

    CAS  PubMed  Google Scholar 

  28. Colby TV. Bronchiolitis. Pathologic considerations. Am J Clin Pathol 1998;109:101–109.

    CAS  PubMed  Google Scholar 

  29. Yousem SA, Dacic S. Idiopathic bronchiolocentric interstitial pneumonia. Mod Pathol 2002;15:1148–1153.

    Article  PubMed  Google Scholar 

  30. Hansell DM, Rubens MB, Padley SP, Wells AU. Obliterative bronchiolitis: individual CT signs of small airways disease and functional correlation. Radiology 1997;203: 721–726.

    CAS  PubMed  Google Scholar 

  31. Hansell DM. HRCT of obliterative bronchiolitis and other small airways diseases. Semin Roentgenol 2001;36:51–65.

    Article  CAS  PubMed  Google Scholar 

  32. Collins J, Blankenbaker D, Stern EJ. CT patterns of bronchiolar disease: what is “tree- in-bud”? AJR Am J Roentgenol 1998;171:365–370.

    CAS  PubMed  Google Scholar 

  33. Muller NL, Miller RR. Diseases of the bronchioles: CT and histopathologic findings. Radiology 1995;196:3–12.

    CAS  PubMed  Google Scholar 

  34. Adler BD, Padley SP, Muller NL, Remy-Jardin M, Remy J. Chronic hypersensitivity pneu-monitis: high-resolution CT and radiographic features in 16 patients. Radiology 1992;185: 91–95.

    CAS  PubMed  Google Scholar 

  35. Sherrick AD, Swensen SJ, Hartman TE. Mosaic pattern of lung attenuation on CT scans: frequency among patients with pulmonary artery hypertension of different causes. AJR Am J Roentgenol 1997;169:79–82.

    CAS  PubMed  Google Scholar 

  36. Davison AG, Heard BE, McAllister WA, Turner-Warwick ME. Cryptogenic organizing pneumonitis. Q J Med 1983;52:382–394.

    CAS  PubMed  Google Scholar 

  37. Epler GR, Colby T V, McLoud TC, Carrington CB, Gaensler EA. Bronchiolitis obliterans organizing pneumonia. N Engl J Med 1985;312:152–158.

    Article  CAS  PubMed  Google Scholar 

  38. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002;165:277–304.

    Google Scholar 

  39. Lazor R, Vandevenne A, Pelletier A, Leclerc P, Court-Fortune I, Cordier JF. Cryptogenic organizing pneumonia. Characteristics of relapses in a series of 48 patients. The Groupe d'Etudes et de Recherche sur les Maladles “Orphelines” Pulmonaires (GERM“O”P). Am J Respir Crit Care Med 2000;162:571–577.

    CAS  PubMed  Google Scholar 

  40. Ujita M, Renzoni EA, Veeraraghavan S, Wells AU, Hansell DM. Organizing pneumonia: perilobular pattern at thin-section CT. Radiology 2004;232:757–761.

    Article  PubMed  Google Scholar 

  41. Kim SJ, Lee KS, Ryu YH, et al. Reversed halo sign on high-resolution CT of cryptogenic organizing pneumonia: diagnostic implications. AJR Am J Roentgenol 2003;180: 1251–1254.

    PubMed  Google Scholar 

  42. Lee JS, Lynch DA, Sharma S, Brown KK, Muller NL. Organizing pneumonia: prognostic implication of high-resolution computed tomography features. J Comput Assist Tomogr 2003;27:260–265.

    Article  PubMed  Google Scholar 

  43. Lee KS, Kullnig P, Hartman TE, Muller NL. Cryptogenic organizing pneumonia: CT findings in 43 patients. AJR Am J Roentgenol 1994;162:543–546.

    CAS  PubMed  Google Scholar 

  44. Yousem SA, Lohr RH, Colby T V. Idiopathic bronchiolitis obliterans organizing pneumonia/ cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors. Mod Pathol 1997;10:864–871.

    CAS  PubMed  Google Scholar 

  45. Cohen AJ, King TE, Jr., Downey GP. Rapidly progressive bronchiolitis obliterans with organizing pneumonia. Am J Respir Crit Care Med 1994;149:1670–1675.

    CAS  PubMed  Google Scholar 

  46. Perez de Llano LA, Soilan JL, Garcia Pais MJ, Mata I, Moreda M, Laserna B. Idiopathic bronchiolitis obliterans with organizing pneumonia presenting with adult respiratory distress syndrome. Respir Med 1998;92:884–886.

    Article  CAS  PubMed  Google Scholar 

  47. Crestani B, Kambouchner M, Soler P, et al. Migratory bronchiolitis obliterans organizing pneumonia after unilateral radiation therapy for breast carcinoma. Eur Respir J 1995;8: 318–321.

    Article  CAS  PubMed  Google Scholar 

  48. Bayle JY, Nesme P, Bejui-Thivolet F, Loire R, Guerin JC, Cordier JF. Migratory organizing pneumonitis “primed” by radiation therapy. Eur Respir J 1995;8:322–326.

    Article  CAS  PubMed  Google Scholar 

  49. Stover DE, Mangino D. Macrolides: a treatment alternative for bronchiolitis obliterans organizing pneumonia? Chest 2005;128:3611–3617.

    Article  PubMed  Google Scholar 

  50. Takigawa N, Segawa Y, Saeki T, et al. Kataoka M, Ida M, Kishino D, Fujiwara K, Ohsumi S, Eguchi K, Takashima S. Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: radiation-induced lung toxicity. Int J Radiat Oncol Biol Phys 2000;48:751–755.

    Article  CAS  PubMed  Google Scholar 

  51. Miwa S, Morita S, Suda T, Suzuki K, Hayakawa H, Chida K, Nakamura H. The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. Sarcoidosis Vasc Diffuse Lung Dis 2004;21:212–218.

    PubMed  Google Scholar 

  52. Kaufman J, Komorowski R. Bronchiolitis obliterans. A new clinical-pathologic complication of irradiation pneumonitis. Chest 1990;97:1243–1244.

    Article  CAS  PubMed  Google Scholar 

  53. Crestani B, Valeyre D, Roden S, Wallaert B, Dalphin JC, Cordier JF. Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM“O”P). Am J Respir Crit Care Med 1998;158:1929–1935.

    CAS  PubMed  Google Scholar 

  54. Roberts CM, Foulcher E, Zaunders JJ, et al. Radiation pneumonitis: a possible lymphocyte-mediated hypersensitivity reaction. Ann Intern Med 1993;118:696–700.

    CAS  PubMed  Google Scholar 

  55. Rubin BK, Henke MO. Immunomodulatory activity and effectiveness of macrolides in chronic airway disease. Chest 2004;125(2 Suppl):70S–78S.

    Article  CAS  PubMed  Google Scholar 

  56. Labro MT, Abdelghaffar H. Immunomodulation by macrolide antibiotics. J Chemother 2001;13:3–8.

    CAS  PubMed  Google Scholar 

  57. Knoop C, Estenne M. Acute and chronic rejection after lung transplantation. Semin Respir Crit Care Med 2006;27:521–533.

    Article  PubMed  Google Scholar 

  58. Abernathy EC, Hruban RH, Baumgartner WA, Reitz BA, Hutchins GM. The two forms of bronchiolitis obliterans in heart-lung transplant recipients. Hum Pathol 1991;22: 1102–1110.

    Article  CAS  PubMed  Google Scholar 

  59. Yousem SA, Duncan SR, Griffith BP. Interstitial and airspace granulation tissue reactions in lung transplant recipients. Am J Surg Pathol 1992;16:877–884.

    Article  CAS  PubMed  Google Scholar 

  60. Milne DS, Gascoigne AD, Ashcroft T, Sviland L, Malcolm AJ, Corris PA. Organizing pneumonia following pulmonary transplantation and the development of obliterative bronchiolitis. Transplantation 1994;57:1757–1762.

    CAS  PubMed  Google Scholar 

  61. Chaparro C, Chamberlain D, Maurer J, Winton T, Dehoyos A, Kesten S. Bronchiolitis obliter-ans organizing pneumonia (BOOP) in lung transplant recipients. Chest 1996;110:1150–1154.

    Article  CAS  PubMed  Google Scholar 

  62. Heng D, Sharples LD, McNeil K, Stewart S, Wreghitt T, Wallwork J. Bronchiolitis obliter-ans syndrome: incidence, natural history, prognosis, and risk factors. J Heart Lung Transplant 1998;17:1255–1263.

    CAS  PubMed  Google Scholar 

  63. Reid KR, McKenzie FN, Menkis AH, Novick RJ, Pflugfelder PW, Kostuk WJ, Ahmad D. Importance of chronic aspiration in recipients of heart-lung transplants. Lancet 1990;336: 206–208.

    Article  CAS  PubMed  Google Scholar 

  64. Miyagawa-Hayashino A, Wain JC, Mark EJ. Lung transplantation biopsy specimens with bronchiolitis obliterans or bronchiolitis obliterans organizing pneumonia due to aspiration. Arch Pathol Lab Med 2005;129:223–226.

    Google Scholar 

  65. Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 2000; 118:1214–1217.

    Article  CAS  PubMed  Google Scholar 

  66. Hadjiliadis D, Duane Davis R, Steele MP, Steele MP, Messier RH, Lau CL, Eubanks SS, Palmer SM. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant 2003;17:363–368.

    Article  PubMed  Google Scholar 

  67. Verleden GM, Dupont LJ, Van Raemdonck DE. Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal? Eur Respir J 2005;25:221–224.

    Article  CAS  PubMed  Google Scholar 

  68. Gammon RB, Bridges TA, al-Nezir H, Alexander CB, Kennedy JI, Jr. Bronchiolitis obliter-ans organizing pneumonia associated with systemic lupus erythematosus. Chest 1992;102: 1171–1174.

    Article  CAS  PubMed  Google Scholar 

  69. Matteson EL, Ike RW. Bronchiolitis obliterans organizing pneumonia and Sjogren's syndrome. J Rheumatol 1990;17:676–679.

    CAS  PubMed  Google Scholar 

  70. Mana F, Mets T, Vincken W, Sennesael J, Vanwaeyenbergh J, Goossens A. The association of bronchiolitis obliterans organizing pneumonia, systemic lupus erythematosus, and Hunner's cystitis. Chest 1993;104:642–644.

    Article  CAS  PubMed  Google Scholar 

  71. Kinney WW, Angelillo VA. Bronchiolitis in systemic lupus erythematosus. Chest 1982;82: 646–649.

    Article  CAS  PubMed  Google Scholar 

  72. Yoshida K, Mouri T, Kuroda S, Suzuki J, Yamauch K, Inoue H, Saito R, Sawai T. A case of Sjogren syndrome associated with bronchiolitis obliterans organizing pneumonia [in Japanese]. Nippon Naika Gakkai Zasshi 2001;90:329–331.

    CAS  PubMed  Google Scholar 

  73. Camus P, Piard F, Ashcroft T, Gal AA, Colby T V. The lung in inflammatory bowel disease. Medicine (Baltimore) 1993;72:151–183.

    CAS  Google Scholar 

  74. Akpinar-Elci M, Travis WD, Lynch DA, Kreiss K. Bronchiolitis obliterans syndrome in popcorn production plant workers. Eur Respir J 2004;24:298–302.

    Article  Google Scholar 

  75. Kreiss K, Gomaa A, Kullman G, Fedan K, Simoes EJ, Enright PL. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 2002;347:330–338.

    Article  PubMed  Google Scholar 

  76. Kern DG, Crausman RS, Durand KT, Nayer A, Kuhn C, 3rd. Flock worker's lung: chronic interstitial lung disease in the nylon flocking industry. Ann Intern Med 1998;129:261–272.

    CAS  PubMed  Google Scholar 

  77. Mann JM, Sha KK, Kline G, Breuer FU, Miller A. World Trade Center dyspnea: bronchioli-tis obliterans with functional improvement: a case report. Am J Ind Med 2005;48:225–229.

    Article  PubMed  Google Scholar 

  78. Schlesinger C, Meyer CA, Veeraraghavan S, Koss MN. Constrictive (obliterative) bronchi-olitis: diagnosis, etiology, and a critical review of the literature. Ann Diagn Pathol 1998; 2:321–334.

    Article  CAS  PubMed  Google Scholar 

  79. Afessa B, Litzow MR, Tefferi A. Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant 2001;28:425–434.

    Article  CAS  PubMed  Google Scholar 

  80. Afessa B, Peters SG. Major complications following hematopoietic stem cell transplantation. Semin Respir Crit Care Med 2006;27:297–309.

    Article  PubMed  Google Scholar 

  81. Hernandez JI, Gomez-Roman J, Rodrigo E, Olmos JM, Gonzàlez-Vela C, Ruiz JC, Val JF, Riancho JA. . Bronchiolitis obliterans and iga nephropathy. A new cause of pulmonary-renal syndrome. Am J Respir Crit Care Med 1997;156:665–668.

    CAS  PubMed  Google Scholar 

  82. Ito M, Nakagawa A, Hirabayashi N, Asai J. Bronchiolitis obliterans in ataxia-telangiectasia. Virchows Arch 1997;430:131–137.

    Article  CAS  PubMed  Google Scholar 

  83. Parto K, Svedstrom E, Majurin ML, Harkonen R, Simell O. Pulmonary manifestations in lysinuric protein intolerance. Chest 1993;104:1176–1182.

    Article  CAS  PubMed  Google Scholar 

  84. Chang H, Wang JS, Tseng HH, Lai RS, Su JM. Histopathological study of Sauropus androg-ynus-associated constrictive bronchiolitis obliterans: a new cause of constrictive bronchioli-tis obliterans. Am J Surg Pathol 1997;21:35–42.

    Article  CAS  PubMed  Google Scholar 

  85. Mahajan L, Kay M, Wyllie R, Steffen R, Goldfarb J. Ulcerative colitis presenting with bron-chiolitis obliterans organizing pneumonia in a pediatric patient. Am J Gastroenterol 1997;92:2123–2124.

    CAS  PubMed  Google Scholar 

  86. D'Ovidio F, Mura M, Tsang M, Waddell TK, Hutcheon MA, Singer LG, Hadjiliadis D, Chaparro C, Gutierrez C, Pierre A, Darling G, Liu M, Keshavjee S. Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. J Thorac Cardiovasc Surg 2005;129:1144–1152.

    Article  PubMed  Google Scholar 

  87. Lee JS, Brown KK, Cool C, Lynch DA. Diffuse pulmonary neuroendocrine cell hyperplasia: radiologic and clinical features. J Comput Assist Tomogr 2002;26:180–184.

    Article  PubMed  Google Scholar 

  88. Aguayo SM, Miller YE, Waldron JA, Jr., Bogin RM, Sunday ME, Staton GW Jr, Beam WR, King TE Jr. Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Engl J Med 1992;327:1285–1288.

    Article  CAS  PubMed  Google Scholar 

  89. Kraft M, Mortenson RL, Colby TV, Newman L, Waldron JA, Jr., King TE, Jr. Cryptogenic con-strictive bronchiolitis. A clinicopathologic study. Am Rev Respir Dis 1993;148:1093–1101.

    CAS  PubMed  Google Scholar 

  90. Scott AI, Sharples LD, Stewart S. Bronchiolitis obliterans syndrome: risk factors and therapeutic strategies. Drugs 2005;65:761–71.

    Article  PubMed  Google Scholar 

  91. Brocker V, Langer F, Fellous TG, Mengel M, Brittan M, Bredt M, Milde S, Welte T, Eder M, Haverich A, Alison MR, Kreipe H, Lehmann U. Fibroblasts of recipient origin contribute to bronchiolitis obliterans in human lung transplants. Am J Respir Crit Care Med 2006; 173:1276–1282.

    Article  PubMed  Google Scholar 

  92. Estenne M, Hertz MI. Bronchiolitis obliterans after human lung transplantation. Am J Respir Crit Care Med 2002;166:440–444.

    Article  PubMed  Google Scholar 

  93. Meyers BF, Lynch J, Trulock EP, Guthrie TJ, Cooper JD, Patterson GA. Lung transplantation: a decade of experience. Ann Surg 1999;230:362–370; discussion 70–71.

    Article  CAS  PubMed  Google Scholar 

  94. Whitehead B, Rees P, Sorensen K, Bull C, Higenbottam TW, Wallwork J, Fabre J, Elliott M, de Leval M. Incidence of obliterative bronchiolitis after heart-lung transplantation in children. J Heart Lung Transplant 1993;12:903–908.

    CAS  PubMed  Google Scholar 

  95. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult lung and heart-lung transplant report—2005. J Heart Lung Transplant 2005;24:956–967.

    Article  PubMed  Google Scholar 

  96. Glanville AR. The role of bronchoscopic surveillance monitoring in the care of lung transplant recipients. Semin Respir Crit Care Med 2006;27:480–491.

    Article  PubMed  Google Scholar 

  97. Sharples LD, McNeil K, Stewart S, Wallwork J. Risk factors for bronchiolitis obliterans: a systematic review of recent publications. J Heart Lung Transplant 2002;21:271–281.

    Article  PubMed  Google Scholar 

  98. Khalifah AP, Hachem RR, Chakinala MM, Yusen RD, Aloush A, Patterson GA, Mohanakumar T, Trulock EP, Walter MJ. Minimal acute rejection after lung transplantation: a risk for bronchiolitis obliterans syndrome. Am J Transplant 2005;5:2022–2030.

    Article  PubMed  Google Scholar 

  99. Hachem RR, Khalifah AP, Chakinala MM, Yusen RD, Aloush AA, Mohanakumar T, Patterson GA, Trulock EP, Walter MJ. The significance of a single episode of minimal acute rejection after lung transplantation. Transplantation 2005;80:1406–1413.

    Article  PubMed  Google Scholar 

  100. Hopkins PM, Aboyoun CL, Chhajed PN, et al. Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med 2004;170: 1022–1026.

    Article  PubMed  Google Scholar 

  101. Girgis RE, Tu I, Berry GJ, et al. Risk factors for the development of obliterative bronchiolitis after lung transplantation. J Heart Lung Transplant 1996;15:1200–1208.

    CAS  PubMed  Google Scholar 

  102. Husain AN, Siddiqui MT, Holmes EW, Chandrasekhar AJ, McCabe M, Radvany R, Garrity ER. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 1999;159:829–833.

    CAS  PubMed  Google Scholar 

  103. Kumar D, Erdman D, Keshavjee S, Peret T, Tellier R, Hadjiliadis D, Johnson G, Ayers M, Siegal D, Humar A. Clinical impact of community-acquired respiratory viruses on bronchi-olitis obliterans after lung transplant. Am J Transplant 2005;5:2031–2036.

    Article  PubMed  Google Scholar 

  104. Vilchez RA, Dauber J, McCurry K, Iacono A, Kusne S. Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft function. Am J Transplant 2003;3:116–120.

    Article  PubMed  Google Scholar 

  105. Gerna G, Vitulo P, Rovida F, Lilleri D, Pellegrini C, Oggionni T, Campanini G, Baldanti F, Revello MG. Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients. J Med Virol 2006;78:408–416.

    Article  PubMed  Google Scholar 

  106. Bando K, Paradis IL, Similo S, Konishi H, Komatsu K, Zullo TG, Yousem SA, Close JM, Zeevi A, Duquesnoy RJ, et al. Obliterative bronchiolitis after lung and heart-lung transplantation. An analysis of risk factors and management. J Thorac Cardiovasc Surg 1995;110:4– 13; discussion-4.

    Article  CAS  PubMed  Google Scholar 

  107. King RC, Binns OA, Rodriguez F, et al. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg 2000;69:1681–1685.

    Article  CAS  PubMed  Google Scholar 

  108. Fisher AJ, Wardle J, Dark JH, Corris PA. Non-immune acute graft injury after lung transplantation and the risk of subsequent bronchiolitis obliterans syndrome (BOS). J Heart Lung Transplant 2002;21:1206–1212.

    Article  PubMed  Google Scholar 

  109. Keogh A, Kaan A, Doran T, Macdonald P, Bryant D, Spratt P. HLA mismatching and outcome in heart, heart-lung, and single lung transplantation. J Heart Lung Transplant 1995;14:444–451.

    CAS  PubMed  Google Scholar 

  110. Wisser W, Wekerle T, Zlabinger G, Senbaclavaci O, Zuckermann A, Klepetko W, Wolner E. Influence of human leukocyte antigen matching on long-term outcome after lung transplantation. J Heart Lung Transplant 1996;15:1209–1216.

    CAS  PubMed  Google Scholar 

  111. Kroshus TJ, Kshettry VR, Savik K, John R, Hertz MI, Bolman RM, 3rd. Risk factors for the development of bronchiolitis obliterans syndrome after lung transplantation. J Thorac Cardiovasc Surg 1997;114:195–202.

    Article  CAS  PubMed  Google Scholar 

  112. Quantz MA, Bennett LE, Meyer DM, Novick RJ. Does human leukocyte antigen matching influence the outcome of lung transplantation? An analysis of 3,549 lung transplantations. J Heart Lung Transplant 2000;19:473–479.

    Article  CAS  PubMed  Google Scholar 

  113. Snyder LD, Palmer SM. Immune mechanisms of lung allograft rejection. Semin Respir Crit Care Med 2006;27:534–543.

    Article  PubMed  Google Scholar 

  114. Chamberlain D, Maurer J, Chaparro C, Idolor L. Evaluation of transbronchial lung biopsy specimens in the diagnosis of bronchiolitis obliterans after lung transplantation. J Heart Lung Transplant 1994;13:963–971.

    CAS  PubMed  Google Scholar 

  115. Hopkins PM, Aboyoun CL, Chhajed PN, Malouf MA, Plit ML, Rainer SP, Glanville AR. Prospective analysis of 1,235 transbronchial lung biopsies in lung transplant recipients. J Heart Lung Transplant 2002;21:1062–1067.

    Article  PubMed  Google Scholar 

  116. Sundaresan S, Trulock EP, Mohanakumar T, Cooper JD, Patterson GA. Prevalence and outcome of bronchiolitis obliterans syndrome after lung transplantation. Washington University Lung Transplant Group. Ann Thorac Surg 1995;60:1341–1346; discussion 6–7.

    Article  CAS  PubMed  Google Scholar 

  117. Nathan SD, Barnett SD, Wohlrab J, Burton N. Bronchiolitis obliterans syndrome: utility of the new guidelines in single lung transplant recipients. J Heart Lung Transplant 2003;22: 427–432.

    Article  PubMed  Google Scholar 

  118. Cooper JD, Billingham M, Egan T, Hertz MI, Higenbottam T, Lynch J, Mauer J, Paradis I, Patterson GA, Smith C, et al.A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation. J Heart Lung Transplant 1993;12:713–716.

    CAS  PubMed  Google Scholar 

  119. Estenne M, Maurer JR, Boehler A, Egan JJ, Frost A, Hertz M, Mallory GB, Snell GI, Yousem S. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 2002;21:297–310.

    Article  PubMed  Google Scholar 

  120. Lama VN, Murray S, Mumford JA, Flaherty KR, Chang A, Toews GB, Peters-Golden M, Martinez FJ. Prognostic value of bronchiolitis obliterans syndrome stage 0-p in single-lung transplant recipients. Am J Respir Crit Care Med 2005;172:379–383.

    Article  PubMed  Google Scholar 

  121. Hachem RR, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, Trulock EP. The predictive value of bronchiolitis obliterans syndrome stage 0-p. Am J Respir Crit Care Med 2004;169:468–472.

    Article  PubMed  Google Scholar 

  122. Studer SM, Orens JB, Rosas I, Krishnan JA, Cope KA, Yang S, Conte JV, Becker PB, Risby TH. Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection. J Heart Lung Transplant 2001;20:1158–1166.

    Article  CAS  PubMed  Google Scholar 

  123. Van Muylem A, Melot C, Antoine M, Knoop C, Estenne M. Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation. Thorax 1997;52:643–647.

    Article  PubMed  Google Scholar 

  124. Lee ES, Gotway MB, Reddy GP, Golden JA, Keith FM, Webb WR. Early bronchiolitis obliterans following lung transplantation: accuracy of epiratory thin-section CT for diagnosis. Radiology 2000;216:472–477.

    CAS  PubMed  Google Scholar 

  125. Siegel MJ, Bhalla S, Gutierrez FR, Hildebolt C, Sweet S. Post-lung transplantation bronchi-olitis obliterans syndrome: usefulness of expiratory thin-section CT for diagnosis. Radiology 2001;220:455–462.

    CAS  PubMed  Google Scholar 

  126. Bankier AA, Van Muylem A, Knoop C, Estenne M, Gevenois PA. Bronchiolitis obliterans syndrome in heart-lung transplant recipients: diagnosis with expiratory CT. Radiology 2001;218:533–539.

    CAS  PubMed  Google Scholar 

  127. Reynaud-Gaubert M, Thomas P, Badier M, Cau P, Giudicelli R, Fuentes P. Early detection of airway involvement in obliterative bronchiolitis after lung transplantation. Functional and bronchoalveolar lavage cell findings. Am J Respir Crit Care Med 2000;161:1924–1929.

    Google Scholar 

  128. Zheng L, Walters EH, Ward C, et al. Airway neutrophilia in stable and bronchiolitis obliter-ans syndrome patients following lung transplantation. Thorax 2000;55:53–59.

    Article  CAS  PubMed  Google Scholar 

  129. DiGiovine B, Lynch JP, 3rd, Martinez FJ, et al. Bronchoalveolar lavage neutrophilia is associated with obliterative bronchiolitis after lung transplantation: role of IL-8. J Immunol 1996;157:4194–4202.

    CAS  PubMed  Google Scholar 

  130. Slebos DJ, Postma DS, Koeter GH, Van Der Bij W, Boezen M, Kauffman HF. Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection. J Heart Lung Transplant 2004;23:532–540.

    Article  PubMed  Google Scholar 

  131. Belperio JA, Keane MP, Burdick MD, et al. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. J Immunol 2002;169:1037–1049.

    CAS  PubMed  Google Scholar 

  132. Belperio JA, Keane MP, Burdick MD, et al. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J Clin Invest 2001;108:547–556.

    CAS  PubMed  Google Scholar 

  133. Belperio JA, DiGiovine B, Keane MP, et al. Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. Transplantation 2002;73: 591–599.

    Article  CAS  PubMed  Google Scholar 

  134. Jackson CH, Sharples LD, McNeil K, Stewart S, Wallwork J. Acute and chronic onset of bronchiolitis obliterans syndrome (BOS): are they different entities? J Heart Lung Transplant 2002;21:658–666.

    Article  PubMed  Google Scholar 

  135. Tamm M, Sharples LD, Higenbottam TW, Stewart S, Wallwork J. Bronchiolitis obliterans syndrome in heart-lung transplantation: surveillance biopsies. Am J Respir Crit Care Med 1997;155:1705–1710.

    CAS  PubMed  Google Scholar 

  136. Brugiere O, Pessione F, Thabut G, et al. Bronchiolitis obliterans syndrome after single-lung transplantation: impact of time to onset on functional pattern and survival. Chest 2002;121: 1883–1889.

    Article  PubMed  Google Scholar 

  137. Kesten S, Maidenberg A, Winton T, Maurer J. Treatment of presumed and proven acute rejection following six months of lung transplant survival. Am J Respir Crit Care Med 1995; 152:1321–1324.

    CAS  PubMed  Google Scholar 

  138. Dusmet M, Maurer J, Winton T, Kesten S. Methotrexate can halt the progression of bronchi-olitis obliterans syndrome in lung transplant recipients. J Heart Lung Transplant 1996; 15:948–954.

    CAS  PubMed  Google Scholar 

  139. Verleden GM, Buyse B, Delcroix M, et al. Cyclophosphamide rescue therapy for chronic rejection after lung transplantation. J Heart Lung Transplant 1999;18:1139–1142.

    Article  CAS  PubMed  Google Scholar 

  140. Cahill BC, Somerville KT, Crompton JA, et al. Early experience with sirolimus in lung transplant recipients with chronic allograft rejection. J Heart Lung Transplant 2003;22:169–176.

    Article  PubMed  Google Scholar 

  141. Ussetti P, Carreno MC, de Pablo A, Gamez P, Varela A. Rapamycin and chronic lung rejection. J Heart Lung Transplant 2004;23:917–918.

    Article  PubMed  Google Scholar 

  142. Brock MV, Borja MC, Ferber L, et al. Induction therapy in lung transplantation: a prospective, controlled clinical trial comparing OKT3, anti-thymocyte globulin, and daclizumab. J Heart Lung Transplant 2001;20:1282–1290.

    Article  CAS  PubMed  Google Scholar 

  143. Garrity ER, Jr., Villanueva J, Bhorade SM, Husain AN, Vigneswaran WT. Low rate of acute lung allograft rejection after the use of daclizumab, an interleukin 2 receptor antibody. Transplantation 2001;71:773–777.

    Article  CAS  PubMed  Google Scholar 

  144. Fisher AJ, Rutherford RM, Bozzino J, Parry G, Dark JH, Corris PA. The safety and efficacy of total lymphoid irradiation in progressive bronchiolitis obliterans syndrome after lung transplantation. Am J Transplant 2005;5:537–543.

    Article  PubMed  Google Scholar 

  145. Salerno CT, Park SJ, Kreykes NS, Kulick DM, Savik K, Hertz MI, Bolman RM 3rd. Adjuvant treatment of refractory lung transplant rejection with extracorporeal photopheresis. J Thorac Cardiovasc Surg 1999;117:1063–1069.

    Article  CAS  PubMed  Google Scholar 

  146. Iacono AT, Johnson BA, Grgurich WF, Youssef JG, Corcoran TE, Seiler DA, Dauber JH, Smaldone GC, Zeevi A, Yousem SA, Fung JJ, Burckart GJ, McCurry KR, Griffith BP. A randomized trial of inhaled cyclosporine in lung-transplant recipients. N Engl J Med 2006;354:141–150.

    Article  PubMed  Google Scholar 

  147. Gerhardt SG, McDyer JF, Girgis RE, Conte J V, Yang SC, Orens JB. Maintenance azithro-mycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. Am J Respir Crit Care Med 2003;168:121–125.

    Article  PubMed  Google Scholar 

  148. Yates B, Murphy DM, Forrest IA, et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2005;172:772–775.

    Article  PubMed  Google Scholar 

  149. Verleden GM, Dupont LJ. Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation. Transplantation 2004;77:1465–1467.

    Article  CAS  PubMed  Google Scholar 

  150. Shitrit D, Bendayan D, Gidon S, Saute M, Bakal I, Kramer MR. Long-term azithromycin use for treatment of bronchiolitis obliterans syndrome in lung transplant recipients. J Heart Lung Transplant 2005;24:1440–1443.

    Article  PubMed  Google Scholar 

  151. Hartwig MG, Appel JZ, Davis RD. Antireflux surgery in the setting of lung transplantation: strategies for treating gastroesophageal reflux disease in a high-risk population. Thorac Surg Clin 2005;15:417–427.

    Article  PubMed  Google Scholar 

  152. Young LR, Hadjiliadis D, Davis RD, Palmer SM. Lung transplantation exacerbates gastro-esophageal reflux disease. Chest 2003;124:1689–1693.

    Article  PubMed  Google Scholar 

  153. Davis RD, Jr., Lau CL, Eubanks S, et al. Improved lung allograft function after fundoplica-tion in patients with gastroesophageal reflux disease undergoing lung transplantation. J Thorac Cardiovasc Surg 2003;125:533–542.

    Article  PubMed  Google Scholar 

  154. Sharma S, Nadrous HF, Peters SG, et al. Pulmonary complications in adult blood and marrow transplant recipients: autopsy findings. Chest 2005;128:1385–1392.

    Article  PubMed  Google Scholar 

  155. Chien JW, Martin PJ, Gooley TA, et al. Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2003;168:208–214.

    Article  PubMed  Google Scholar 

  156. Khalid M, Al Saghir A, Saleemi S, et al. Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study. Eur Respir J 2005;25:490–493.

    Article  CAS  PubMed  Google Scholar 

  157. St John RC, Gadek JE, Tutschka PJ, Kapoor N, Dorinsky PM. Analysis of airflow obstruction by bronchoalveolar lavage following bone marrow transplantation. Implications for pathogenesis and treatment. Chest 1990;98:600–607.

    Article  CAS  PubMed  Google Scholar 

  158. Dudek AZ, Mahaseth H, DeFor TE, Weisdorf DJ. Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biol Blood Marrow Transplant 2003;9:657–666.

    Article  PubMed  Google Scholar 

  159. Hayes-Jordan A, Benaim E, Richardson S, Joglar J, Srivastava DK, Bowman L, Shochat SJ. Open lung biopsy in pediatric bone marrow transplant patients. J Pediatr Surg 2002;37: 446–452.

    Article  Google Scholar 

  160. Sanchez J, Torres A, Serrano J, Romàn J, Martín C, Pérula L, Martínez F, Gómez P. Long-term follow-up of immunosuppressive treatment for obstructive airways disease after alloge-neic bone marrow transplantation. Bone Marrow Transplant 1997;20:403–408.

    Article  CAS  PubMed  Google Scholar 

  161. Ratjen F, Rjabko O, Kremens B. High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. Bone Marrow Transplant 2005;36:135–138.

    Article  CAS  PubMed  Google Scholar 

  162. Fullmer JJ, Fan LL, Dishop MK, Rodgers C, Krance R. Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade. Pediatrics 2005;116:767–770.

    Article  PubMed  Google Scholar 

  163. Favaloro R, Bertolotti A, Gomez C, et al. Lung transplant at the Favaloro Foundation: a 13-year experience. Transplant Proc 2004;36:1689–1691.

    Article  CAS  PubMed  Google Scholar 

  164. Ishii T, Manabe A, Ebihara Y, et al. Improvement in bronchiolitis obliterans organizing pneumonia in a child after allogeneic bone marrow transplantation by a combination of oral prednisolone and low dose erythromycin. Bone Marrow Transplant 2000;26:907–910.

    Article  CAS  PubMed  Google Scholar 

  165. Palmas A, Tefferi A, Myers JL, et al. Late-onset noninfectious pulmonary complications after allogeneic bone marrow transplantation. Br J Haematol 1998;100:680–687.

    Article  CAS  PubMed  Google Scholar 

  166. Dodd JD, Muller NL. Bronchiolitis obliterans organizing pneumonia after bone marrow transplantation: high-resolution computed tomography findings in 4 patients. J Comput Assist Tomogr 2005;29:540–543.

    Article  PubMed  Google Scholar 

  167. Mathew P, Bozeman P, Krance RA, Brenner MK, Heslop HE. Bronchiolitis obliterans organizing pneumonia (BOOP) in children after allogeneic bone marrow transplantation. Bone Marrow Transplant 1994;13:221–223.

    CAS  PubMed  Google Scholar 

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Lynch, J.P., Saggar, R., Suh, R.D., Fishbein, M.C. (2009). Bronchiolar Disorders. In: Baughman, R.P., Carbone, R.G., Bottino, G. (eds) Pulmonary Arterial Hypertension and Interstitial Lung Diseases. Humana Press. https://doi.org/10.1007/978-1-60327-074-8_6

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