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Humanized Model to Study Leukemic Stem Cells

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Leukemia

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 538))

Summary

The xenotransplantation model has been instrumental for the identification and characterization of human leukemic stem cells. In this chapter we will discuss the development of the immunodeficient model in the understanding of leukemogenesis, describe the different models of immunodeficiency now available and their values, as well as describe the methods used for the purification of LSCs. We will concentrate on the model of acute myeloid leukemia, as it was the first type of leukemia for which the xenotransplantation model was developed.

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Acknowledgments

The author thanks Mr. Christopher Ridler and Dr. Daniel Pearce for their assistance in the preparation of this manuscript.

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Authors and Affiliations

  1. Cancer Research UK, London Research Institute, Haematopoietic Stem Cell Laboratory, 44 Lincoln’s Inn Fields, WC2A 3PX, London, UK

    Dominique Bonnet

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  1. Dominique Bonnet
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Correspondence to Dominique Bonnet .

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Editors and Affiliations

  1. King's College London, The University of London, London, UK

    Chi Wai Eric So (Professor and Chair in Leukaemia Biology) (Professor and Chair in Leukaemia Biology)

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Bonnet, D. (2009). Humanized Model to Study Leukemic Stem Cells. In: Eric So, C.W. (eds) Leukemia. Methods in Molecular Biology™, vol 538. Humana Press. https://doi.org/10.1007/978-1-59745-418-6_12

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  • DOI: https://doi.org/10.1007/978-1-59745-418-6_12

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-989-5

  • Online ISBN: 978-1-59745-418-6

  • eBook Packages: Springer Protocols

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