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Epidemiology of Multiple Primary Cancers

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Cancer Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 471))

Summary

Cancer patients have a 20% higher risk of new primary cancer compared with the general population. Approximately one third of cancer survivors aged >60 years were diagnosed more than once with another cancer. As the number of cancer survivors and of older people increases, occurrence of multiple primary cancers is also likely to increase. An increasing interest from epidemiologic and clinical perspectives seems logical. This chapter begins with the risk pattern of multiple cancers in the population of a developed country with high survival rates. Multiple cancers comprise two or more primary cancers occurring in an individual that originate in a primary site or tissue and that are neither an extension, nor a recurrence or metastasis. Studies of multiple cancers have been mainly conducted in population-based settings, and more recently in clinical trials and case control studies leading to further understanding of risk factors for the development of multiple primary cancers. These factors include an inherited predisposition to cancer; the usual carcinogenic or cancer-promoting aspects of lifestyle, hormonal, and environmental factors; treatment of the previous primary cancer; and increased surveillance of cancer survivors. Finally, implication on research strategies and clinical practice are discussed, covering the whole range of epidemiologic approach.

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References

  1. Fraumeni, J. F. J., Curtis, R., Edwards, B. K., Tucker, M. A. (2006) Introduction. Bethesda, MD: National Cancer Institute. pp. 1–7.

    Google Scholar 

  2. Sankila, R., Pukkala, E., Teppo, L. (1995) Risk of subsequent malignant neoplasms among 470,000 cancer patients in Finland, 1953–1991. Int J Cancer 60, 464–70.

    Article  CAS  PubMed  Google Scholar 

  3. Mariotto, A. B., Rowland, J. H., Ries, L. A., Scoppa, S., Feuer, E. J. (2007) Multiple cancer prevalence: a growing challenge in long-term survivorship. Cancer Epidemiol Biomark Prev 16, 566–71.

    Article  Google Scholar 

  4. Parkin, D. M., Bray, F., Ferlay, J., Pisani, P. (2005) Global cancer statistics, 2002. CA Cancer J Clin 55, 74–108.

    Article  PubMed  Google Scholar 

  5. Janssen-Heijnen, M. L., Houterman, S., Lemmens, V. E., Louwman, M. W., Maas, H. A., Coebergh, J. W. (2005) Prognostic impact of increasing age and co-morbidity in cancer patients: a population-based approach. Crit Rev Oncol Hematol 55, 231–40.

    Article  PubMed  Google Scholar 

  6. Soerjomataram, I., Louwman, M. W., Ribot, J. G., Roukema, J. A., Coebergh, J. W. (2007) An overview of prognostic fac- tors for long-term survivors of breast cancer. Breast Cancer Res Treat 107, 309–330.

    Article  PubMed  CAS  Google Scholar 

  7. Howe, H. L. (2003) A review of the definition for multiple primary cancers in the United States. Workshop proceedings from December 4–6, 2002, in Princeton, New Jersey. Springfield (IL): North American Association of Central Cancer Registries.

    Google Scholar 

  8. Johnson, C. H., Adamo, M. (2007) SEER Program Coding and Staging Manual 2007. Bethesda, MD: National Cancer Institute.

    Google Scholar 

  9. Working Group Report. (2005) International rules for multiple primary cancers (ICD-0, third edition). Eur J Cancer Prev 14, 307–8.

    Article  Google Scholar 

  10. Vriesema, J. L., Aben, K. K., Witjes, J. A., Kiemeney, L. A., Schalken, J. A. (2001) Superficial and metachronous invasive bladder carcinomas are clonally related. Int J Cancer 93, 699–702.

    Article  CAS  PubMed  Google Scholar 

  11. Aben, K. K., Witjes, J. A., van Dijck, J. A., Schalken, J. A., Verbeek, A. L., Kiemeney, L. A. (2000) Lower incidence of urothelial cell carcinoma due to the concept of a clonal origin. Eur J Cancer 36, 2385–9.

    Article  CAS  PubMed  Google Scholar 

  12. Harari, P. M. (1998) Re: Distinguishing second primary tumors from lung metas-tases in patients with head and neck squa-mous cell carcinoma. J Natl Cancer Inst 90, 1571.

    Article  CAS  PubMed  Google Scholar 

  13. Smith, R. E., Bryant, J., DeCillis, A., Anderson, S. (2003) Acute myeloid leukemia and myelodysplastic syndrome after doxoru-bicin-cyclophosphamide adjuvant therapy for operable breast cancer: the National Surgical Adjuvant Breast and Bowel Project Experience. J Clin Oncol 21, 1195–204.

    Article  CAS  PubMed  Google Scholar 

  14. Huang, E., Buchholz, T. A., Meric, F., Krishnamurthy, S., Mirza, N. Q., Ames, F. C., Feig, B. W., Kuerer, H. M., Ross, M. I., Singletary, S. E., McNeese, M. D., Strom, E. A., Hunt, K. K. (2002) Classifying local disease recurrences after breast conservation therapy based on location and histology: new primary tumors have more favorable outcomes than true local disease recurrences. Cancer 95, 2059–67.

    Article  PubMed  Google Scholar 

  15. Crocetti, E., Lecker, S., Buiatti, E., Storm, H. H. (1996) Problems related to the coding of multiple primary cancers. Eur J Cancer 32A, 1366–70.

    Article  CAS  PubMed  Google Scholar 

  16. Hotes, J. L., Ellison, L. F., Howe, H. L., Friesen, I., Kohler, B. (2004) Variation in breast cancer counts using SEER and IARC multiple primary coding rules. Cancer Causes Control 15, 185–91.

    Article  PubMed  Google Scholar 

  17. Scelo, G., Boffetta, P., Autier, P., Hemminki, K., Pukkala, E., Olsen, J. H., Weiderpass, E., Tracey, E., Brewster, D. H., McBride, M. L., Kliewer, E. V., Tonita, J. M., Pompe-Kirn, V., Chia, K. S., Jonasson, J. G., Mar-tos, C., Giblin, M., Brennan, P. (2007) Associations between ocular melanoma and other primary cancers: an international population-based study. Int J Cancer 120, 152–9.

    Article  CAS  PubMed  Google Scholar 

  18. Scelo, G., Boffetta, P., Corbex, M., Chia, K. S., Hemminki, K., Friis, S., Pukkala, E., Wei-derpass, E., McBride, M. L., Tracey, E., Brewster, D. H., Pompe-Kirn, V., Kliewer, E. V., Tonita, J. M., Martos, C., Jonasson, J. G., Brennan, P. (2007) Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Cancer Causes Control 18, 269–78.

    Article  PubMed  Google Scholar 

  19. Mellemkjaer, L., Friis, S., Olsen, J. H., Scelo, G., Hemminki, K., Tracey, E., Andersen, A., Brewster, D. H., Pukkala, E., McBride, M. L., Kliewer, E. V., Tonita, J. M., Kee-Seng, C., Pompe-Kirn, V., Martos, C., Jonasson, J. G., Boffetta, P., Brennan, P. (2006) Risk of second cancer among women with breast cancer. Int J Cancer 118, 2285–92.

    Article  CAS  PubMed  Google Scholar 

  20. Tuohimaa, P., Pukkala, E., Scelo, G., Olsen, J. H., Brewster, D. H., Hemminki, K., Tracey, E., Weiderpass, E., Kliewer, E. V., Pompe-Kirn, V., McBride, M. L., Mar-tos, C., Chia, K. S., Tonita, J. M., Jonas-son, J. G., Boffetta, P., Brennan, P. (2007) Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation. Eur J Cancer 43, 1701–1712.

    Article  CAS  PubMed  Google Scholar 

  21. Grant, W. B. (2007) A meta-analysis of second cancers after a diagnosis of non-melanoma skin cancer: additional evidence that solar ultraviolet-B irradiance reduces the risk of internal cancers. J Steroid Bio-chem Mol Biol 103, 668–74.

    Article  CAS  Google Scholar 

  22. de Vries, E., Soerjomataram, I., Houter-man, S., Louwman, M. W., Coebergh, J. W. (2007) Decreased risk of prostate cancer after skin cancer diagnosis: a protective role of ultraviolet radiation? Am J Epidemiol 165, 966–72.

    Article  PubMed  Google Scholar 

  23. van Leeuwen, F. E., Travis, L. B. (2005) Second Cancers, 7 ed. Philadelphia. PA: Lippin-cott Williams and Wilkins. pp. 2575–602.

    Google Scholar 

  24. Travis, L. B. (2006) The epidemiology of second primary cancers. Cancer Epidemiol Biomarkers Prev 15, 2020–6.

    Article  PubMed  Google Scholar 

  25. Curtis, R., Ries, L. A. G. (2006) Methods. Bethesda, MD: National Cancer Institute. pp. 1–7.

    Google Scholar 

  26. Schoenberg, B. S., Myers, M. H. (1977) Statistical methods for studying multiple primary malignant neoplasms. Cancer 40, 1892–8.

    Article  CAS  PubMed  Google Scholar 

  27. Begg, C. B., Zhang, Z. F., Sun, M., Herr, H. W., Schantz, S. P. (1995) Methodolo g y for evaluating the incidence of second primary cancers with application to smoking-related cancers from the Surveillance, Epidemiology, and End Results (SEER) program. Am J Epidemiol 142, 653–65.

    CAS  PubMed  Google Scholar 

  28. Cutler, S. J., Ederer, F. (1958) Maximum utilization of the life table method in analyzing survival. J Chronic Dis 8, 699–712.

    Article  CAS  PubMed  Google Scholar 

  29. Gooley, T. A., Leisenring, W., Crowley, J., Storer, B. E. (1999) Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 18, 695–706.

    Article  CAS  PubMed  Google Scholar 

  30. Yu, G. P., Schantz, S. P., Neugut, A. I., Zhang, Z. F. (2006) Incidences and trends of second cancers in female breast cancer patients: a fixed inception cohort-based analysis (United States). Cancer Causes Control 17, 411–20.

    Article  PubMed  Google Scholar 

  31. Yasui, Y., Liu, Y., Neglia, J. P., Friedman, D. L., Bhatia, S., Meadows, A. T., Diller, L. R., Mertens, A. C., Whitton, J., Robison, L. L. (2003) A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancers. Am J Epidemiol 158, 1108–13.

    Article  PubMed  Google Scholar 

  32. Travis, L. B. (2002) Therapy-associated solid tumors. Acta Oncol. 41, 323–33.

    Article  PubMed  Google Scholar 

  33. Largent, J. A., Capanu, M., Bernstein, L., Langholz, B., Mellemkjaer, L., Malone, K. E., Begg, C. B., Haile, R. W., Lynch, C. F., Anton-Culver, H., Wolitzer, A., Bernstein, J. L. (2007) Reproductive History and Risk of Second Primary Breast Cancer: the WECARE Study. Cancer Epidemiol Biomarkers Prev 16, 906–911.

    Article  PubMed  Google Scholar 

  34. Travis, L. B., Rabkin, C. S., Brown, L. M., Allan, J. M., Alter, B. P., Ambrosone, C. B., Begg, C. B., Caporaso, N., Chanock, S., DeMichele, A., Figg, W. D., Gospodarow-icz, M. K., Hall, E. J., Hisada, M., Inskip, P., Kleinerman, R., Little, J. B., Malkin, D., Ng, A. K., Offit, K., Pui, C. H., Robison, L. L., Rothman, N., Shields, P. G., Strong, L., Taniguchi, T., Tucker, M. A., Greene, M. H. (2006) Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations. J Natl Cancer Inst 98, 15–25.

    Article  PubMed  Google Scholar 

  35. Garber, J. E., Offit, K. (2005) Hereditary cancer predisposition syndromes. J Clin Oncol 23, 276–92.

    Article  PubMed  Google Scholar 

  36. Fearon, E. R. (1997) Human cancer syndromes: clues to the origin and nature of cancer. Science 278, 1043–50.

    Article  CAS  PubMed  Google Scholar 

  37. Nagy, R., Sweet, K., Eng, C. (2004) Highly penetrant hereditary cancer syndromes. Oncogene 23, 6445–70.

    Article  CAS  PubMed  Google Scholar 

  38. Hill, D. A., Gilbert, E., Dores, G. M., Gospodarowicz, M., van Leeuwen, F. E., Holowaty, E., Glimelius, B., Andersson, M., Wiklund, T., Lynch, C. F., Van't Veer, M., Storm, H., Pukkala, E., Stovall, M., Curtis, R. E., Allan, J. M., Boice, J. D., Travis, L. B. (2005) Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors. Blood 106, 3358–65.

    Article  CAS  PubMed  Google Scholar 

  39. Landgren, O., Pfeiffer, R. M., Stewart, L., Gridley, G., Mellemkjaer, L., Hemminki, K., Goldin, L. R., Travis, L. B. (2007) Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. Int J Cancer 120, 1099–102.

    Article  CAS  PubMed  Google Scholar 

  40. Trentham-Dietz, A., Newcomb, P. A., Nichols, H. B., Hampton, J. M. (2007) Breast cancer risk factors and second primary malignancies among women with breast cancer. Breast Cancer Res Treat 105, 359–68.

    Article  Google Scholar 

  41. Kmet, L. M., Cook, L. S., Weiss, N. S., Schwartz, S. M., White, E. (2003) Risk factors for colorectal cancer following breast cancer. Breast Cancer Res Treat 79, 143–7.

    Article  CAS  PubMed  Google Scholar 

  42. Hisada, M., Garber, J. E., Fung, C. Y., Fraumeni, J. F., Jr., Li, F. P. (1998) Multiple primary cancers in families with Li-Fraumeni syndrome. J Natl Cancer Inst 90, 606–11.

    Article  CAS  PubMed  Google Scholar 

  43. Hemminki, K., Ji, J., Forsti, A. (2007) Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk. Cancer Res 67, 868–70.

    Article  CAS  PubMed  Google Scholar 

  44. Hemminki, K., Li, X. (2005) Familial risk for lung cancer by histology and age of onset: evidence for recessive inheritance. Exp Lung Res. 31, 205–15.

    Article  PubMed  Google Scholar 

  45. Soerjomataram, I., Louwman, W. J., de Vries, E., Lemmens, V. E., Klokman, W. J., Coebergh, J. W. (2005) Primary malignancy after primary female breast cancer in the South of the Netherlands, 1972–2001. Breast Cancer Res Treat 93, 91–5.

    Article  CAS  PubMed  Google Scholar 

  46. Soerjomataram, I., Louwman, W. J.,Lemmens V. E., de Vries, E., Klokman, W. J., Coebergh, J. W. (2005) Risks of second primary breast and urogenital cancer following female breast cancer in the south of The Netherlands, 1972–2001. Eur J Cancer 41, 2331–7.

    Article  CAS  PubMed  Google Scholar 

  47. Raymond, J. S., Hogue, C. J. (2006) Multiple primary tumours in women following breast cancer, 1973–2000. Br J Cancer 94, 1745–50.

    CAS  PubMed  Google Scholar 

  48. Metcalfe, K. A., Lynch, H. T., Ghadirian, P., Tung, N., Olivotto, I. A., Foulkes, W. D., Warner, E., Olopade, O., Eisen, A., Weber, B., McLennan, J., Sun, P., Narod, S. A. (2005) The risk of ovarian cancer after breast cancer in BRCA1 and BRCA2 carriers. Gynecol Oncol 96, 222–6.

    Article  CAS  PubMed  Google Scholar 

  49. Metcalfe, K., L ynch, H. T., Ghadirian, P., Tung, N., Olivotto, I., Warner, E., Olopade, O. I., Eisen, A., Weber, B., McLennan, J., Sun, P., Foulkes, W. D., Narod, S. A. (2004) Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol 22, 2328–35.

    Article  CAS  PubMed  Google Scholar 

  50. Lynch, H. T., Shaw, T. G., Lynch, J. F. (2004) Inherited predisposition to cancer: a historical overview. Am J Med Genet C Semin Med Genet 129, 5–22.

    Article  Google Scholar 

  51. Meijers-Heijboer, H., Wijnen, J., Vasen, H., Wasielewski, M., Wagner, A., Hollestelle, A., Elstrodt, F., van den Bos, R., de Snoo,A., Fat, G. T., Brekelmans, C., Jagmo-han, S., Franken, P., Verkuijlen, P., van den Ouweland, A., Chapman, P., Tops, C., Moslein, G., Burn, J., Lynch, H., Klijn, J., Fodde, R., Schutte, M. (2003) The CHEK2 1100delC mutation identifies families with a hereditary breast and color-ectal cancer phenotype. Am J Hum Genet 72, 1308–14.

    Article  CAS  PubMed  Google Scholar 

  52. Dong, C., Hemminki, K. (2001) Multiple primary cancers of the colon, breast and skin (melanoma) as models for polygenic cancers. Int J Cancer. 92, 883–7.

    Article  CAS  PubMed  Google Scholar 

  53. Balmain, A., Gray, J., Ponder, B. (2003) The genetics and genomics of cancer. Nat Genet 33 Suppl, 238–44.

    Article  CAS  PubMed  Google Scholar 

  54. Levi, F., Randimbison, L., Maspoli, M., Te, V. C., La Vecchia, C. (2007) Second neoplasms after oesophageal cancer. Int J Cancer 121, 694–7.

    Article  CAS  PubMed  Google Scholar 

  55. Shen, M., Boffetta, P., Olsen, J. H., Andersen, A., Hemminki, K., Pukkala, E., Tracey, E., Brewster, D. H., McBride, M. L., Pompe-Kirn, V., Kliewer, E. V., Tonita, J. M., Chia, K. S., Martos, C., Jonasson, J. G., Colin, D., Scelo, G., Brennan, P. (2006) A pooled analysis of second primary pancreatic cancer. Am J Epidemiol 163, 502–11.

    Article  PubMed  Google Scholar 

  56. Brown, L. M., McCarron, P., Freedman, D. M. (2006) New malignancies following cancer of the buccal cavity and phar ynx. Bethesda, MD: National Cancer Institute. pp. 1–7.

    Google Scholar 

  57. Caporaso, N., Dodd, K. W., Tucker, M. A. (2006) New malignancies following cancer of the respiratory tract. Bethesda, MD: National Cancer Institute. 1–7.

    Google Scholar 

  58. Dikshit, R. P., Boffetta, P., Bouchardy, C., Merletti, F., Crosignani, P., Cuchi, T., Ardanaz, E., Brennan, P. (2005) Risk factors for the development of second primary tumors among men after laryngeal and hypopharyngeal carcinoma. Cancer 103, 2326–33.

    Article  PubMed  Google Scholar 

  59. Swerdlow, A. J., Barber, J. A., Hudson, G. V., Cunningham, D., Gupta, R. K., Hancock, B. W., Horwich, A., Lister, T. A., Linch, D. C. (2000) Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 18, 498–509.

    CAS  PubMed  Google Scholar 

  60. Tucker, M. A., Murray, N., Shaw, E. G., Ettinger, D. S., Mabry, M., Huber, M. H., Feld, R., Shepherd, F. A., Johnson, D. H., Grant, S. C., Aisner, J., Johnson, B. E. (1997) Second primary cancers related to smoking and treatment of small-cell lung cancer. Lung Cancer Working Cadre. J Natl Cancer Inst 89, 1782–8.

    Article  CAS  PubMed  Google Scholar 

  61. Khuri, F. R., Kim, E. S., Lee, J. J., Winn, R. J., Benner, S. E., Lippman, S. M., Fu, K. K., Cooper, J. S., Vokes, E. E., Chamberlain, R. M., Williams, B., Pajak, T. F., Goepfert, H., Hong, W. K. (2001) The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial. Cancer Epidemiol Biomark Prev 10, 823–9.

    CAS  Google Scholar 

  62. Gilbert, E. S., Stovall, M., Gospodarowicz, M., Van Leeuwen, F. E., Andersson, M., Glimelius, B., Joensuu, T., Lynch, C. F., Curtis, R. E., Holowaty, E., Storm, H., Pukkala, E., van't Veer, M. B., Fraumeni, J. F., Boice, J. D., Jr., Clarke, E. A., Travis, L. B. (2003) Lung cancer after treatment for Hodgkin's disease: focus on radiation effects. Radiat Res 159, 161–73.

    Article  CAS  PubMed  Google Scholar 

  63. Travis, L. B., Gospodarowicz, M., Curtis, R. E., Clarke, E. A., Andersson, M., Glimelius, B., Joensuu, T., Lynch, C. F., van Leeuwen, F. E., Holowaty, E., Storm, H., Glimelius, I., Pukkala, E., Stovall, M., Fraumeni, J. F., Jr., Boice, J. D., Jr., Gilbert, E. (2002) Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease. J Natl Cancer Inst 94, 182–92.

    PubMed  Google Scholar 

  64. Do, K. A., Johnson, M. M., Lee, J. J., Wu, X. F., Dong, Q., Hong, W. K., Khuri, F. R., Spitz, M. R. (2004) Longitudinal study of smoking patterns in relation to the development of smoking-related secondary primary tumors in patients with upper aerodigestive tract malignancies. Cancer 101, 2837–42.

    Article  PubMed  Google Scholar 

  65. Pike, M. C., Pearce, C. L., Wu, A. H. (2004) Prevention of cancers of the breast, endometrium and ovary. Oncogene 23, 6379–91.

    Article  CAS  PubMed  Google Scholar 

  66. Samanic, C., Chow, W. H., Gridley, G., Jarvholm, B., Fraumeni, J. F., Jr. (2006) Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 17, 901–9.

    Article  PubMed  Google Scholar 

  67. Mysliwiec, P. A., Cronin, K. A., Schatzkin, A. (2006) New Malignancies following cancer of the colon, rectum, and Anus. Bethesda, MD: National Cancer Institute. 1–7.

    Google Scholar 

  68. Dignam, J. J., Wieand, K., Johnson, K. A., Fisher, B., Xu, L., Mamounas, E. P. (2003) Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer. J Natl Cancer Inst 95, 1467–76.

    CAS  PubMed  Google Scholar 

  69. Dignam, J. J., Wieand, K., Johnson, K. A., Raich, P., Anderson, S. J., Somkin, C., Wickerham, D. L. (2006) Effects of obesity and race on prognosis in lymph node-nega- tive, estrogen receptor-negative breast cancer. Breast Cancer Res Treat 97, 245–54.

    Article  PubMed  Google Scholar 

  70. Dignam, J. J., Polite, B. N., Yothers, G., Raich, P., Colangelo, L., O'Connell, M. J., Wolmark, N. (2006) Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 98, 1647–54.

    Article  PubMed  Google Scholar 

  71. van Leeuwen, F. E., Klokman, W. J., Stovall, M., Dahler, E. C., van't Veer, M. B., Noordijk, E. M., Crommelin, M. A., Aleman, B. M., Broeks, A., Gospodarowicz, M., Travis, L. B., Russell, N. S. (2003) Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease. J Natl Cancer Inst 95, 971–80.

    Article  PubMed  Google Scholar 

  72. Swerdlow, A. J., Jones, M. E. (2005) Tamoxifen treatment for breast cancer and risk of endometrial cancer: a case-control study. J Natl Cancer Inst 97, 375–84.

    Article  CAS  PubMed  Google Scholar 

  73. Kleinerman, R. A., Kosary, C., Hildesheim, A. (2006) New malignancies following cancer of the cervix uteri, vagina, and vulva. Bethesda, MD: National Cancer Institute. 1–7.

    Google Scholar 

  74. Hemminki, K., Dong, C., Vaittinen, P. (2000) Second primary cancer after in situ and invasive cervical cancer. Epidemiology 11, 457–61.

    Article  CAS  PubMed  Google Scholar 

  75. Levi, F., Te, V. C., Randimbison, L., La Vecchia, C. (2001) Second primary cancers after in situ and invasive cervical cancer. Epidemiology 12, 281–2.

    Article  CAS  PubMed  Google Scholar 

  76. Vinokurova, S., Wentzensen, N., Einenkel, J., Klaes, R., Ziegert, C., Melsheimer, P., Sartor, H., Horn, L. C., Hockel, M., von Knebel Doeberitz, M. (2005) Clonal history of papillomavirus-induced dysplasia in the female lower genital tract. J Natl Cancer Inst 97, 1816–21.

    Article  CAS  PubMed  Google Scholar 

  77. Brennan, P., Scelo, G., Hemminki, K., Melle-mkjaer, L., Tracey, E., Andersen, A., Brewster, D. H., Pukkala, E., McBride, M. L., Kliewer, E. V., Tonita, J. M., Seow, A., Pompe-Kirn, V., Martos, C., Jonasson, J. G., Colin, D., Boffetta, P. (2005) Second primary cancers among 109 000 cases of non-Hodgkin's lym-phoma. Br J Cancer 93, 159–66.

    Article  CAS  PubMed  Google Scholar 

  78. Dores, G. M., Cote, T. R., Travis, L. B. (2006) New malignancies following Hodgkin lymphoma, Non-Hodgkin Lymphoma, and Myeloma. Bethesda, MD: National Cancer Institute. 1–7.

    Google Scholar 

  79. Wang, C. C., Chen, M. L., Hsu, K. H., Lee, S. P., Chen, T. C., Chang, Y. S., Tsang, N. M., Hong, J. H. (2000) Second malignant tumors in patients with nasopharyngeal carcinoma and their association with Epstein-Barr virus. Int J Cancer 87, 228–31.

    Article  CAS  PubMed  Google Scholar 

  80. Schwartz, R. S. (2001) Immunodeficiency, immunosuppression, and susceptibility to neoplasms. J Natl Cancer Inst Monogr 5–9.

    Google Scholar 

  81. Clifford, G. M., Polesel, J., Rickenbach, M., Dal Maso, L., Keiser, O., Kofler, A., Rapiti, E., Levi, F., Jundt, G., Fisch, T., Bordoni, A., De Weck, D., Franceschi, S. (2005) Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst 97, 425–32.

    Article  PubMed  Google Scholar 

  82. Hemminki, K., Jiang, Y., Steineck, G. (2003) Skin cancer and non-Hodgkin's lymphoma as second malignancies. markers of impaired immune function? Eur J Cancer 39, 223–9.

    Article  CAS  PubMed  Google Scholar 

  83. Metayer, C., Lynch, C. F., Clarke, E. A., Glimelius, B., Storm, H., Pukkala, E., Joen-suu, T., van Leeuwen, F. E., van't Veer, M. B., Curtis, R. E., Holowaty, E. J., Anders-son, M., Wiklund, T., Gospodarowicz, M., Travis, L. B. (2000) Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence. J Clin Oncol 18, 2435–43.

    CAS  PubMed  Google Scholar 

  84. Allan, J. M., Travis, L. B. (2005) Mechanisms of therapy-related carcinogenesis. Nat Rev Cancer 5, 943–55.

    Article  CAS  PubMed  Google Scholar 

  85. Dores, G. M., Metayer, C., Curtis, R. E., Lynch, C. F., Clarke, E. A., Glimelius, B., Storm, H., Pukkala, E., van Leeuwen, F. E., Holowaty, E. J., Andersson, M., Wiklund, T., Joensuu, T., van't Veer, M. B., Stovall, M., Gospodarowicz, M., Travis, L. B. (2002) Second malignant neoplasms among long-term survivors of Hodgkin's disease: a population-based evaluation over 25 years. J Clin Oncol 20, 3484–94.

    Article  PubMed  Google Scholar 

  86. van Leeuwen, F. E., Klokman, W. J., Veer, M. B., Hagenbeek, A., Krol, A. D., Vetter, U. A., Schaapveld, M., van Heerde, P., Burgers, J. M., Somers, R., Aleman, B. M. (2000) Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood. J Clin Oncol 18, 487–97.

    PubMed  Google Scholar 

  87. Boice, J. D. Ionizing radiation. 3 ed. New York: Oxford University Press. 259–93.

    Google Scholar 

  88. Kleinerman, R. A., Tucker, M. A., Abramson, D. H., Seddon, J. M., Tarone, R. E., Frau-meni, J. F., Jr. (2007) Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst 99, 24–31.

    Article  PubMed  Google Scholar 

  89. Wong, F. L., Boice, J. D., Jr., Abramson, D. H., Tarone, R. E., Kleinerman, R. A., Stovall, M., Goldman, M. B., Seddon, J. M., Tarbell, N., Fraumeni, J. F., Jr., Li, F. P. (1997) Cancer incidence after retino-blastoma. Radiation dose and sarcoma risk. JAMA 278, 1262–7.

    Article  CAS  PubMed  Google Scholar 

  90. Travis, L. B., Curtis, R. E., Glimelius, B., Holowaty, E. J., Van Leeuwen, F. E., Lynch, C. F., Hagenbeek, A., Stovall, M., Banks, P. M., Adami, J., et al. (1995) Bladder and kidney cancer following cyclophosphamide therapy for non-Hodg-kin's lymphoma. J Natl Cancer Inst 87, 524–30.

    Article  CAS  PubMed  Google Scholar 

  91. Henderson, T. O., Whitton, J., Stovall, M., Mertens, A. C., Mitby, P., Friedman, D., Strong, L. C., Hammond, S., Neglia, J. P., Meadows, A. T., Robison, L., Diller, L. (2007) Secondary sarcomas in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 99, 300–8.

    Article  PubMed  Google Scholar 

  92. Mudie, N. Y., Swerdlow, A. J., Higgins, C. D., Smith, P., Qiao, Z., Hancock, B. W., Hoskin, P. J., Linch, D. C. (2006) Risk of second malignancy after non-Hodgkin's lymphoma: a British Cohort Study. J Clin Oncol 24, 1568–74.

    Article  PubMed  Google Scholar 

  93. Garwicz, S., Anderson, H., Olsen, J. H., Dollner, H., Hertz, H., Jonmundsson, G., Langmark, F., Lanning, M., Moller, T., Sankila, R., Tulinius, H. (2000) Second malignant neoplasms after cancer in childhood and adolescence: a population-based case-control study in the 5 Nordic countries. The Nordic Society for Pediatric Hematology and Oncology. The Association of the Nordic Cancer Registries. Int J Cancer 88, 672–8.

    Article  CAS  PubMed  Google Scholar 

  94. Travis, L. B., Hill, D. A., Dores, G. M., Gospodarowicz, M., van Leeuwen, F. E., Holowaty, E., Glimelius, B., Andersson, M., Wiklund, T., Lynch, C. F., Van't Veer, M. B., Glimelius, I., Storm, H., Pukkala, E., Stovall, M., Curtis, R., Boice, J. D., Jr., Gilbert, E. (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 290, 465–75.

    Article  PubMed  Google Scholar 

  95. Guerin, S., Guibout, C., Shamsaldin, A., Dondon, M. G., Diallo, I., Hawkins, M., Oberlin, O., Hartmann, O., Michon, J., Le Deley, M. C., de Vathaire, F. (2007) Concomitant chemo-radiotherapy and local dose of radiation as risk factors for second malignant neoplasms after solid cancer in childhood: a case-control study. Int J Cancer 120, 96–102.

    Article  CAS  PubMed  Google Scholar 

  96. Rubino, C., de Vathaire, F., Shamsaldin, A., Labbe, M., Le, M. G. (2003) Radiation dose, chemotherapy, hormonal treatment and risk of second cancer after breast cancer treatment. Br J Cancer 89, 840–6.

    Article  CAS  PubMed  Google Scholar 

  97. (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365, 1687–717.

    Google Scholar 

  98. Fisher, B., Costantino, J. P., Wickerham, D. L., Redmond, C. K., Kavanah, M., Cronin, W. M., Vogel, V., Robidoux, A., Dimitrov, N., Atkins, J., Daly, M., Wieand, S., Tan-Chiu, E., Ford, L., Wolmark, N. (1998) Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90, 1371–88.

    Article  CAS  PubMed  Google Scholar 

  99. Bergman, L., Beelen, M. L., Gallee, M. P., Hollema, H., Benraadt, J., van Leeuwen, F. E. (2000) Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen. Lancet 356, 881–7.

    Article  CAS  PubMed  Google Scholar 

  100. Bernstein, J. L., Thompson, W. D., Risch, N., Holford, T. R. (1992) Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer. Am J Epidemiol 136, 925–36.

    CAS  PubMed  Google Scholar 

  101. (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 351, 1451–67.

    Google Scholar 

  102. Teodorovic, I., Isabelle, M., Carbone, A., Passioukov, A., Lejeune, S., Jamine, D., Therasse, P., Gloghini, A., Dinjens, W. N., Lam, K. H., Oomen, M. H., Spatz, A., Rat-cliffe, C., Knox, K., Mager, R., Kerr, D., Pez-zella, F., van Damme, B., van de Vijver, M., van Boven, H., Morente, M. M., Alonso, S., Kerjaschki, D., Pammer, J., Lopez-Guerrero, J. A., Llombart Bosch, A., van Veen, E. B., Oosterhuis, J. W., Riegman, P. H. (2006) TuBaFrost 6: virtual microscopy in virtual tumour banking. Eur J Cancer 42, 3110–6.

    Article  CAS  PubMed  Google Scholar 

  103. Leong, P. P., Rezai, B., Koch, W. M., Reed, A., Eisele, D., Lee, D. J., Sidransky, D., Jen, J., Westra, W. H. (1998) Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. J Natl Cancer Inst 90, 972–7.

    Article  CAS  PubMed  Google Scholar 

  104. Blokx, W. A., Lesterhuis, J. J., Andriessen, M. P., Verdijk, M. A., Punt, K. J., Ligten-berg, M. J. (2007) CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma. Am J Surg Pathol 31, 637–41.

    Article  PubMed  Google Scholar 

  105. Geurts, T. W., Nederlof, P. M., van den Brekel, M. W., van't Veer, L. J., de Jong, D., Hart, A. A., van Zandwijk, N., Klomp, H., Balm, A. J., van Velthuysen, M. L. (2005) Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: metastasis or second primary? Clin Cancer Res 11, 6608–14.

    Article  PubMed  Google Scholar 

  106. Travis, L. B., Hill, D., Dores, G. M., Gospodarowicz, M., van Leeuwen, F. E., Holowaty, E., Glimelius, B., Andersson, M., Pukkala, E., Lynch, C. F., Pee, D., Smith, S. A., Van't Veer, M. B., Joensuu, T., Storm, H., Stovall, M., Boice, J. D., Jr., Gilbert, E., Gail, M. H. (2005) Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 97, 1428–37.

    Article  PubMed  Google Scholar 

  107. Hijiya, N., Hudson, M. M., Lensing, S., Zacher, M., Onciu, M., Behm, F. G., Raz-zouk, B. I., Ribeiro, R. C., Rubnitz, J. E., Sandlund, J. T., Rivera, G. K., Evans, W. E., Relling, M. V., Pui, C. H. (2007) Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphob-lastic leukemia. JAMA 297, 1207–15.

    Article  CAS  PubMed  Google Scholar 

  108. Schonfeld, S. J., Gilbert, E. S., Dores, G. M., Lynch, C. F., Hodgson, D. C., Hall, P., Storm, H., Andersen, A., Pukkala, E., Holowaty, E., Kaijser, M., Andersson, M., Joensuu, H., Fossa, S. D., Allan, J. M., Travis, L. B. (2006) Acute myeloid leukemia following Hodgkin lymphoma: a population-based study of 35,511 patients. J Natl Cancer Inst 98, 215–8.

    Article  PubMed  Google Scholar 

  109. Howard, R. A., Gilbert, E. S., Chen, B. E., Hall, P., Storm, H., Pukkala, E., Langmark, F., Kaijser, M., Andersson, M., Joensuu, H., Fossa, S. D., Travis, L. B. (2007) Leukemia following breast cancer: an international population-based study of 376,825 women. Breast Cancer Res Treat 105, 359–368.

    Article  PubMed  Google Scholar 

  110. Travis, L. B., Holowaty, E. J., Bergfeldt, K., Lynch, C. F., Kohler, B. A., Wiklund, T., Curtis, R. E., Hall, P., Andersson, M., Pukkala, E., Sturgeon, J., Stovall, M. (1999) Risk of leukemia after platinum-based chemotherapy for ovarian cancer. N Engl J Med 340, 351–7.

    Article  CAS  PubMed  Google Scholar 

  111. Kaldor, J. M., Day, N. E., Pettersson, F., Clarke, E. A., Pedersen, D., Mehnert, W., Bell, J., Host, H., Prior, P., Karjalainen, S., et al. (1990) Leukemia following chemotherapy for ovarian cancer. N Engl J Med 322, 1–6.

    Article  CAS  PubMed  Google Scholar 

  112. Robinson, D., Moller, H., Hor wich, A. (2007) Mortality and incidence of second cancers following treatment for testicular cancer. Br J Cancer 96, 529–33.

    Article  CAS  PubMed  Google Scholar 

  113. Travis, L. B., Andersson, M., Gospodaro-wicz, M., van Leeuwen, F. E., Bergfeldt, K., Lynch, C. F., Curtis, R. E., Kohler, B. A., Wiklund, T., Storm, H., Holowaty, E., Hall, P., Pukkala, E., Sleijfer, D. T., Clarke, E. A., Boice, J. D., Jr., Stovall, M., Gilbert, E. (2000) Treatment-associated leukemia following testicular cancer. J Natl Cancer Inst 92, 1165–71.

    Article  CAS  PubMed  Google Scholar 

  114. Le Deley, M. C., Leblanc, T., Shamsaldin, A., Raquin, M. A., Lacour, B., Sommelet, D., Chompret, A., Cayuela, J. M., Bayle, C., Bernheim, A., de Vathaire, F., Vassal, G., Hill, C. (2003) Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Societe Francaise d'Oncologie Pediatrique. J Clin Oncol 21, 1074–81.

    Article  PubMed  CAS  Google Scholar 

  115. Neglia, J. P., Friedman, D. L., Yasui, Y., Mertens, A. C., Hammond, S., Stovall, M., Donaldson, S. S., Meadows, A. T., Robison, L. L. (2001) Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 93, 618–29.

    Article  CAS  PubMed  Google Scholar 

  116. Kaldor, J. M., Day, N. E., Kittelmann, B., Pettersson, F., Langmark, F., Pedersen, D., Prior, P., Neal, F., Karjalainen, S., Bell, J., et al. (1995) Bladder tumours following chemotherapy and radiotherapy for ovarian cancer: a case-control study. Int J Cancer 63, 1–6.

    Article  CAS  PubMed  Google Scholar 

  117. Hawkins, M. M., Wilson, L. M., Bur ton, H. S., Potok, M. H., Winter, D. L., Marsden, H. B., Stovall, M. A. (1996) Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 88, 270–8.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Public Health, Erasmus MC, Rotterdam, The Netherlands

    Isabelle Soerjomataram

  2. Comprehensive Cancer Centre South, AE Eindhoven, The Netherlands

    Jan Willem Coebergh

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  1. Isabelle Soerjomataram
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  2. Jan Willem Coebergh
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  1. Division of Cancer Control and Population Sciences Bethesda, Maryland, 20892, USA

    Mukesh Verma PhD

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Soerjomataram, I., Coebergh, J.W. (2009). Epidemiology of Multiple Primary Cancers. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 471. Humana Press. https://doi.org/10.1007/978-1-59745-416-2_5

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  • DOI: https://doi.org/10.1007/978-1-59745-416-2_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-987-1

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