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Pristane-Induced Arthritis in the Rat

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Arthritis Research

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 136))

Abstract

A chronic relapsing arthritis develops after a single subcutaneous injection of small amounts of pristane; the pristane induced arthritis (PIA) model in the rat. PIA is characterized by a sudden onset of disease 2 wk after induction. The main pathological features of PIA include edema accompanied by an acute phase response, infiltration into the joint of mononuclear and polymorphonuclear cells, pannus formation, and erosion of cartilage and bone. PIA is a disease that is largely T-cell dependent that can be adoptively transferred by activated CD4+ T-cells. PIA in rats is followed clinically by macroscopic scoring and is characterized by an early acute phase of severe inflammation after onset that eventually gradually disappears to be followed by less severe relapsing phases of new inflamed joints and increasing cartilage erosion and joint deformity. PIA can be diagnosed by biochemical analyzes in plasma that reflects systemic inflammation (α1-acid glycoprotein (AGP) and IL-6) and cartilage erosion (COMP).

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Author information

Authors and Affiliations

  1. Medical Inflammation Research, Lund, Sweden

    Peter Olofsson

  2. Medical Inflammation Research, Lund University, Lund, Sweden

    Rikard Holmdahl

Authors
  1. Peter Olofsson
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  2. Rikard Holmdahl
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Editor information

Editors and Affiliations

  1. The Kennedy Institute of Rheumatology, Imperial College London, London, UK

    Andrew P. Cope

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© 2007 Humana Press Inc., Totowa, NJ

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Olofsson, P., Holmdahl, R. (2007). Pristane-Induced Arthritis in the Rat. In: Cope, A.P. (eds) Arthritis Research. Methods in Molecular Medicine, vol 136. Humana Press. https://doi.org/10.1007/978-1-59745-402-5_19

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  • DOI: https://doi.org/10.1007/978-1-59745-402-5_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-918-5

  • Online ISBN: 978-1-59745-402-5

  • eBook Packages: Springer Protocols

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