Abstract
The analysis of DNA sequence polymorphisms and SNPs (single nucleotide polymorphisms) can provide insights into the evolutionary forces acting on populations and species. Available population-genetic methods, and particularly those based on the coalescent theory, have become the primary framework to analyze such DNA polymorphism data. Here, I explain some essential analytical methods for interpreting DNA polymorphism data and also describe the basic functionalities of the DnaSP software. DnaSP is a multi-propose program that allows conducting exhaustive DNA polymorphism analysis using a graphical user-friendly interface.
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Acknowledgments
We thank Sergios-Orestis Kolokotronis for his helpful comments and suggestions on the manuscript. This work was funded by grant BFU2007-62927 from the Dirección General de Investigación Científica y Técnica (Spain), and by grant 2005SGR00166 from Comissió Interdepartamental de Recerca i Innovació Tecnològica de Catalunya (Spain).
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Rozas, J. (2009). DNA Sequence Polymorphism Analysis Using DnaSP. In: Posada, D. (eds) Bioinformatics for DNA Sequence Analysis. Methods in Molecular Biology, vol 537. Humana Press. https://doi.org/10.1007/978-1-59745-251-9_17
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DOI: https://doi.org/10.1007/978-1-59745-251-9_17
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