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Prostate (Cancer) Stem Cells

  • Chapter
Prostate Cancer

Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

The prostate stem cell concept described in this chapter was studied in our laboratory, where we provided experimental immunophenotypic evidence of the presence of keratin, androgen receptor, neuroendocrine markers, and c-Met protooncogene in unique populations of normal developing and malignant human prostate epithelial cells. The characteristic responses of these stem cells to growth factors and neoadjuvant hormonal therapy supported the cancer stem cell concept, and, if successfully applied to human prostate cancer specimens, could reveal new therapeutic targets.

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Authors and Affiliations

  1. Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Jack A. Schalken

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  1. Jack A. Schalken
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Editors and Affiliations

  1. Emory University School of Medicine, Atlanta, GA

    Leland W. K. Chung PhD

  2. Johns Hopkins University School of Medicine, Baltimore, MD

    William B. Isaacs PhD

  3. Prostate Cancer Foundation, Santa Monica, CA

    Jonathan W. Simons MD

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© 2007 Humana Press Inc., Totowa, NJ

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Schalken, J.A. (2007). Prostate (Cancer) Stem Cells. In: Chung, L.W.K., Isaacs, W.B., Simons, J.W. (eds) Prostate Cancer. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59745-224-3_4

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  • DOI: https://doi.org/10.1007/978-1-59745-224-3_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-696-2

  • Online ISBN: 978-1-59745-224-3

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