Abstract
Changes in chromatin structure can affect gene transcription, cell proliferation, and differentiation (1). The structural remodeling of chromatin associated with gene expression is mediated in part by the coordinated targeting of various chromatin modifying enzymes to gene regulatory regions via recruitment by transcription factors and accessory proteins (2). The dynamic interplay between various classes of enzymes that acetylate/deacetylate, phosphorylate/dephosphorylate, and methylate/demethylate proteins determines the pattern of chemically modified amino acid residues in the N-terminal tail domains of the core histones that comprise nucleosomes. The specific pattern of histone modification, or “histone code,” is then interpreted by proteins that selectively bind to modified residues, providing a platform for the protein machinery responsible for establishing the chromatin into a transcriptionally silent or activated state (3,4).
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Hobbs, C.A., Gilmour, S.K. (2006). Role of Polyamines in the Regulation of Chromatin Acetylation. In: Wang, JY., Casero, R.A. (eds) Polyamine Cell Signaling. Humana Press. https://doi.org/10.1007/978-1-59745-145-1_5
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DOI: https://doi.org/10.1007/978-1-59745-145-1_5
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