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Lung Cancer

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Principles of Molecular Medicine

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide today. An increasing understanding of the pathogenesis of lung cancer at the cellular and molecular levels has revealed that lung cancer arises as the result of the accumulation of multiple genetic and epigenetic alterations. These include chromosomal abnormalities, aberrant DNA methylation, the activation of protooncogenes, the inactivation of tumor suppressor genes, and changes in signal transduction pathways. This chapter provides a brief summary of the recent advances in understanding the molecular biology of human lung cancer with emphasis on tumoracquired deregulation of cell proliferation and survival. Key Words: Apoptosis; chromosomal abnormality; epigenetic alternation; lung cancer; oncogene; proliferation; signal transduction; telomerase; tumor suppressor gene; tumorigenesis.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL

    Lei Xiao

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  1. Lei Xiao
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  1. Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill, NC

    Marschall S. Runge MD, PhD  & Cam Patterson MD  & 

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Xiao, L. (2006). Lung Cancer. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_75

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_75

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