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Pediatric Malignancies

IORT Alone or With EBRT

  • Chapter
Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

In pediatric tumors, local control when combined with intensive adjuvant systemic therapy often leads to long-term survival. In other words, because of greater sensitivity of systemic disease to chemotherapy, local control becomes of greater importance than in many adult malignancies. For example, in adult pancreatic cancer, improved local control does not translate into improved survival due to the high rate of systemic failure because of inadequate chemotherapy whereas an approximately 30% 5-year survival is seen in pediatric group IV rhabdomyosarcoma patients (1) and in metastatic Ewing’s sarcoma patients (2).

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Authors
  1. Paula J. Schomberg
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  2. Thomas E. Merchant
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  3. Gerald Haase
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  4. Javier Aristu
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Editor information

Editors and Affiliations

  1. Mayo Clinic and Mayo Medical School, Rochester, MN, USA

    Leonard L. Gunderson MD, MS (Professor and Chair of Oncology) (Professor and Chair of Oncology)

  2. Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Christopher G. Willet MD

  3. Albert Einstein College of Medicine and Beth Israel Cancer Center, New York, NY, USA

    Louis B. Harrison MD

  4. University Hospital Gregorio Marañón, Madrid, Spain

    Felipe A. Calvo MD (Chair of Oncology) (Chair of Oncology)

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© 1999 Springer Science+Business Media New York

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Schomberg, P.J., Merchant, T.E., Haase, G., Aristu, J. (1999). Pediatric Malignancies. In: Gunderson, L.L., Willet, C.G., Harrison, L.B., Calvo, F.A. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-696-6_25

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  • DOI: https://doi.org/10.1007/978-1-59259-696-6_25

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5576-3

  • Online ISBN: 978-1-59259-696-6

  • eBook Packages: Springer Book Archive

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