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Gonadal Hormone Regulation of Synaptic Plasticity in the Brain

What Is the Mechanism?

  • Chapter
Neurosteroids

Part of the book series: Contemporary Endocrinology ((COE,volume 16))

Abstract

Throughout the life span, the brain continues to be shaped and modified by the external world acting through the release and actions of circulating hormones and endogenous growth factors and neurotransmitters. Receptors for steroid hormones and thyroid hormone were the first transcription regulators discovered for eukaryotic cells (1). Besides helping to catalyze the discovery of other transcription regulators (2,3), the steroid-thyroid hormone family of receptors has provided an important tool for elucidating the sites and cellular mechanisms by which circulating hormones exert permanent develop-mental effects (e.g., sexual differentiation) and reversible and often cyclic effects on the mature brain (4).

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McEwen, B.S. (1999). Gonadal Hormone Regulation of Synaptic Plasticity in the Brain. In: Baulieu, EE., Robel, P., Schumacher, M. (eds) Neurosteroids. Contemporary Endocrinology, vol 16. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-693-5_14

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