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Protective and Regenerative Properties of GDNF in the Central Nervous System

  • Chapter
Neuroprotective Signal Transduction

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Glial cell line-derived neurotrophic factor (GDNF) was isolated and cloned by Lin and colleagues (Lin et al., 1993, 1994) as part of a concerted effort to identify new trophic factors for midbrain dopamine (DA) neurons. Since the initial description of GDNF in 1993, studies from a number of laboratories have confirmed its potent effects on DA neurons. In addition, GDNF has been found to play an intricate role in the survival and development of a diverse set of neuronal and nonneuronal cells.

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Authors
  1. Wayne A. Cass
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  2. Cecilia M. Kearns
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  3. Don M. Gash
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Editors and Affiliations

  1. University of Kentucky, Lexington, KY, USA

    Mark P. Mattson

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Cass, W.A., Kearns, C.M., Gash, D.M. (1998). Protective and Regenerative Properties of GDNF in the Central Nervous System. In: Mattson, M.P. (eds) Neuroprotective Signal Transduction. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-475-7_8

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  • DOI: https://doi.org/10.1007/978-1-59259-475-7_8

  • Publisher Name: Humana Press, Totowa, NJ

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