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Cytotoxic T-Lymphocytes Reactive to Patient Major Histocompatibility Complex Proteins for Therapy of Brain Tumors

  • Chapter
Brain Tumor Immunotherapy

Abstract

In patients with primary malignant brain tumors (BT), tumor growth has defied conventional therapies comprised of surgery, radiation, and chemotherapy (1–3). The growth and expansion of tumor cells throughout normal brain neuropil often cannot be contained without destroying normal brain tissue. Immunotherapy (IT) strategies became of interest to neuro-oncology researchers, because regeneration of normal brain is considered limited, at best, and because the potential for selectivity in tumor over normal cell destruction is seemingly inherent in the immune system.

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Authors
  1. Carol A. Kruse PhD
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  2. David Rubinstein MD
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Editors and Affiliations

  1. School of Medicine, University of California at Los Angeles, CA, USA

    Linda M. Liau MD, PhD , Donald P. Becker MD  & Timothy F. Cloughesy MD ,  & 

  2. Department of Pathology and Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC, USA

    Darell D. Bigner MD, PhD

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Kruse, C.A., Rubinstein, D. (2001). Cytotoxic T-Lymphocytes Reactive to Patient Major Histocompatibility Complex Proteins for Therapy of Brain Tumors. In: Liau, L.M., Becker, D.P., Cloughesy, T.F., Bigner, D.D. (eds) Brain Tumor Immunotherapy. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-035-3_7

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  • DOI: https://doi.org/10.1007/978-1-59259-035-3_7

  • Publisher Name: Humana Press, Totowa, NJ

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