Abstract
Arrestins have now been implicated in the actions of virtually every G protein-coupled receptor (GPCR) for which they have been examined. Originally discovered for their role in the turnoff of visual perception, their newly discovered pleotropic functions in the cellular and physiological actions of GPCRs not only illuminate new mechanisms of signal transduction but also offer new avenues for therapeutic utility. Below, in this introductory chapter, we provide a short historical description and synopsis of how arrestins conceptually became associated with the function of GPCRs.
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Acknowledgments
Work in the Caron/Barak group at Duke University has been supported by grants for the United States National Institutes of Health (5R37-MH073853, 5P30-DA029925, 4U19-MH082441, 1R33CA191198); a gift from the Pall Family Foundation and the Howard Hughes Medical Institutes (1992-2005).
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Caron, M.G., Barak, L.S. (2019). A Brief History of the β-Arrestins. In: Scott, M., Laporte, S. (eds) Beta-Arrestins. Methods in Molecular Biology, vol 1957. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9158-7_1
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DOI: https://doi.org/10.1007/978-1-4939-9158-7_1
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