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Cellular and Vascular Components of Tertiary Lymphoid Structures

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Tertiary Lymphoid Structures

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1845))

Abstract

Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules, and local activation of resident stromal cells, including lymphatic endothelial cells. B-cell proliferation and affinity maturation toward locally displayed autoantigens have been demonstrated at these sites, known as tertiary lymphoid structures (TLS). TLS formation during chronic inflammation has been associated with local disease persistence and progression, as well as increased systemic manifestations. While bearing a similar histological structure to SLO, the signals that regulate TLS and SLO formation can diverge and a series of pro-inflammatory cytokines have been ascribed as responsible for TLS formation at different anatomical sites. Moreover, for a long time the structural compartment that regulates TLS homeostasis, including survival and recirculation of leucocytes has been neglected. In this chapter, we summarize the novel data available on TLS formation, structural organization, and the functional and anatomical links connecting TLS and SLOs.

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Acknowledgments

F.B. is an ARUK Senior Fellow and is part of the NIHR Birmingham Biomedical Research Centre.

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Authors and Affiliations

  1. Laboratoire d’Immunologie, Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire (IBMC), CNRS UPR 3572, University of Strasbourg, Strasbourg, France

    Christopher George Mueller

  2. Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK

    Saba Nayar, David Gardner & Francesca Barone

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  1. Christopher George Mueller
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  2. Saba Nayar
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  3. David Gardner
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  4. Francesca Barone
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Correspondence to Francesca Barone .

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  1. Laboratory “Cancer, Immune Control and Escape”, UMRS 1138 INSERM, Cordeliers Research Center, Sorbonne University, UMR 1138, Paris Descartes University, Sorbonne Paris City, UMR 1138, Paris, France

    Marie-Caroline Dieu-Nosjean

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Mueller, C.G., Nayar, S., Gardner, D., Barone, F. (2018). Cellular and Vascular Components of Tertiary Lymphoid Structures. In: Dieu-Nosjean, MC. (eds) Tertiary Lymphoid Structures. Methods in Molecular Biology, vol 1845. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8709-2_2

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  • DOI: https://doi.org/10.1007/978-1-4939-8709-2_2

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