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Exosomal MicroRNAs as Potential Biomarkers in Neuropsychiatric Disorders

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MicroRNA Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1733))

Abstract

This chapter will discuss the potential use of microRNAs, particularly those located in peripherally-isolated exosomes, as biomarkers in neuropsychiatric disorders. These extracellular vesicles are released as a form of cell-to-cell communication and may mediate the soma-to-germline transmission of brain-relevant information, thereby potentially contributing to the inter- or transgenerational transmission of behavioral traits. Recent novel methods allow for the enrichment of peripheral exosomes specifically released by neurons and astrocytes and may provide valuable brain-relevant biosignatures of disease.

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Author information

Authors and Affiliations

  1. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Gabriel R. Fries & Joao Quevedo

  2. Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Joao Quevedo

  3. Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA

    Joao Quevedo

  4. Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

    Joao Quevedo

Authors
  1. Gabriel R. Fries
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  2. Joao Quevedo
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Corresponding author

Correspondence to Gabriel R. Fries .

Editor information

Editors and Affiliations

  1. Department of Integrative Anatomical Sciences, USC, Keck School of Medicine, Los Angeles, California, USA

    Shao-Yao Ying

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Fries, G.R., Quevedo, J. (2018). Exosomal MicroRNAs as Potential Biomarkers in Neuropsychiatric Disorders. In: Ying, SY. (eds) MicroRNA Protocols . Methods in Molecular Biology, vol 1733. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7601-0_6

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  • DOI: https://doi.org/10.1007/978-1-4939-7601-0_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7600-3

  • Online ISBN: 978-1-4939-7601-0

  • eBook Packages: Springer Protocols

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