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Evaluating Nanomedicines: Obstacles and Advancements

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Characterization of Nanoparticles Intended for Drug Delivery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1682))

Abstract

Continued advancements in nanotechnology are expanding the boundaries of medical research, most notably as drug delivery agents for treatment against cancer. Drug delivery with nanotechnology can offer greater control over the biodistribution of therapeutic agents to improve the therapeutic index. In the last 20 years, a number of nanomedicines have transitioned into the clinic. As nanomedicines evolve, techniques to properly evaluate their safety and efficacy must also evolve. Characterization methods for nano-based materials must be adapted to the demands of nanomedicine developers and regulators. This second edition book provides updated characterization protocols designed to address the clinical potential of nanomedicines during their preclinical development. In this chapter, the characterization challenges of nanoparticles intended for drug delivery will be discussed, along with examples of advancements and improvements in nanomedicine characterization.

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Acknowledgment

This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

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Authors and Affiliations

  1. Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA

    Magdalena Swierczewska & Rachael M. Crist

  2. Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA

    Scott E. McNeil

Authors
  1. Magdalena Swierczewska
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  2. Rachael M. Crist
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  3. Scott E. McNeil
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Corresponding author

Correspondence to Scott E. McNeil .

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Editors and Affiliations

  1. Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

    Scott E. McNeil

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Swierczewska, M., Crist, R.M., McNeil, S.E. (2018). Evaluating Nanomedicines: Obstacles and Advancements. In: McNeil, S. (eds) Characterization of Nanoparticles Intended for Drug Delivery. Methods in Molecular Biology, vol 1682. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7352-1_1

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  • DOI: https://doi.org/10.1007/978-1-4939-7352-1_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7350-7

  • Online ISBN: 978-1-4939-7352-1

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