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Protein Function Prediction

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Functional Genomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1654))

Abstract

Protein function is a concept that can have different interpretations in different biological contexts, and the number and diversity of novel proteins identified by large-scale “omics” technologies poses increasingly new challenges. In this review we explore current strategies used to predict protein function focused on high-throughput sequence analysis, as for example, inference based on sequence similarity, sequence composition, structure, and protein–protein interaction. Various prediction strategies are discussed together with illustrative workflows highlighting the use of some benchmark tools and knowledge bases in the field.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR, Brazil

    Leonardo Magalhães Cruz

  2. Sector of Professional and Technological Education, Federal University of Paraná (UFPR), Curitiba, PR, Brazil

    Leonardo Magalhães Cruz, Sheyla Trefflich, Vinícius Almir Weiss & Mauro Antônio Alves Castro

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  1. Leonardo Magalhães Cruz
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  2. Sheyla Trefflich
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  3. Vinícius Almir Weiss
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  4. Mauro Antônio Alves Castro
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Correspondence to Leonardo Magalhães Cruz .

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Editors and Affiliations

  1. Chair of Biochemistry and Molecular Medicine, Division of Functional Genomics, Faculty of Health, School of Medicine, Center for Biochemical Research and Education ZBAF, Witten/Herdecke University, Witten, Germany

    Michael Kaufmann

  2. Chair of Biochemistry and Molecular Medicine, Division of Functional Genomics, Faculty of Health, School of Medicine, Center for Biochemical Research and Education ZBAF, Witten/Herdecke University, Witten, Germany

    Claudia Klinger

  3. Chair of Biochemistry and Molecular Medicine, Division of Functional Genomics, Faculty of Health, School of Medicine, Center for Biochemical Research and Education ZBAF, Witten/Herdecke University, Witten, Germany

    Andreas Savelsbergh

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Cruz, L.M., Trefflich, S., Weiss, V.A., Castro, M.A.A. (2017). Protein Function Prediction. In: Kaufmann, M., Klinger, C., Savelsbergh, A. (eds) Functional Genomics. Methods in Molecular Biology, vol 1654. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7231-9_5

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  • DOI: https://doi.org/10.1007/978-1-4939-7231-9_5

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