Abstract
With the advancement of translational research, particularly in the field of cancer, it is now imperative to have models which more clearly reflect patient heterogeneity. Patient derived xenograft (PDX) models, which involve the orthotopic implantation of breast tumors into immune-compromised mice, recapitulate the native tumor biology. Despite the considerable challenges that establishing PDX models present, they are the ultimate model to study tumorigenesis of refractory disease and for assessing the efficacy of new pharmaceutical compounds.
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Acknowledgements
Funding is acknowledged from the Irish Cancer Society Collaborative Cancer Research Centre BREAST-PREDICT grant, CCRC13GAL and Breast Cancer Ireland. No conflict of interest is declared by the authors.
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Varešlija, D., Cocchiglia, S., Byrne, C., Young, L. (2017). Patient-Derived Xenografts of Breast Cancer. In: Martin, F., Stein, T., Howlin, J. (eds) Mammary Gland Development. Methods in Molecular Biology, vol 1501. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6475-8_17
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DOI: https://doi.org/10.1007/978-1-4939-6475-8_17
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