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Animal Stroke Model: Ischemia–Reperfusion and Intracerebral Hemorrhage

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

Stroke is a major health issue worldwide—one with serious financial and public health implications. As a result, ongoing clinical research on novel and improved stroke therapies is not only pertinent but also paramount. Due to the complexity of a stroke-like event and its many sequelae, devising usable methods and experimental models are necessary to study and better understand the pathophysiological processes that ensue. As it stands, animal models that simulate stroke-like events have proven to be the most logical and effective options in regards to experimental studies. A number of animal stroke models exist and have been demonstrated in previous studies on ischemic as well as hemorrhagic stroke. Considering the efficiency and reproducibility of animal models, here, we introduce an ischemic stroke model induced by middle cerebral artery occlusion (MCAO) and an intracerebral hemorrhagic stroke model induced by collagenase injection. The models outlined here have been proven to demonstrate the clinical relevance desired for use in continued research on stroke pathophysiology and the study of future therapeutic options.

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Acknowledgments

This work was partially supported by the program of National Natural Science Foundation of China (81573867), and Scientific Special Funding of Capital Health Development (No. 2011-1001-03).

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Authors and Affiliations

  1. Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Chang Chun Road 45, Beijing, 100053, China

    Changhong Ren, Jinhuan Gao & Xunming Ji M.D., Ph.D.

  2. Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA

    Christopher Sy & Yuchuan Ding

Authors
  1. Changhong Ren
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  2. Christopher Sy
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  3. Jinhuan Gao
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  4. Yuchuan Ding
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  5. Xunming Ji M.D., Ph.D.
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Corresponding author

Correspondence to Xunming Ji M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

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Ren, C., Sy, C., Gao, J., Ding, Y., Ji, X. (2016). Animal Stroke Model: Ischemia–Reperfusion and Intracerebral Hemorrhage. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_21

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_21

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3814-8

  • Online ISBN: 978-1-4939-3816-2

  • eBook Packages: Springer Protocols

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