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Female Tract Cytokines and Developmental Programming in Embryos

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Cell Signaling During Mammalian Early Embryo Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 843))

Abstract

In the physiological situation, cytokines are pivotal mediators of communication between the maternal tract and the embryo. Compelling evidence shows that cytokines emanating from the oviduct and uterus confer a sophisticated mechanism for ‘fine-tuning’ of embryo development, influencing a range of cellular events from cell survival and metabolism, through division and differentiation, and potentially exerting long-term impact through epigenetic remodelling. The balance between survival agents, including GM-CSF, CSF1, LIF, HB-EGF and IGFII, against apoptosis-inducing factors such as TNFα, TRAIL and IFNg, influence the course of preimplantation development, causing embryos to develop normally, adapt to varying maternal environments, or in some cases to arrest and undergo demise. Maternal cytokine-mediated pathways help mediate the biological effects of embryo programming, embryo plasticity and adaptation, and maternal tract quality control. Thus maternal cytokines exert influence not only on fertility and pregnancy progression but on the developmental trajectory and health of offspring. Defining a clear understanding of the biology of cytokine networks influencing the embryo is essential to support optimal outcomes in natural and assisted conception.

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Conflict of Interest Statement

Sarah Robertson is an inventor on patents concerning utility of GM-CSF in IVF culture medium and receives royalty income from ORIGIO A/S. Jeremy Thompson is a consultant to Cook Medical Pty. Ltd. and has patents on methods for in vitro oocyte maturation.

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Authors and Affiliations

  1. The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Medical School, Frome Road, 5005, Adelaide, SA, Australia

    Sarah A. Robertson, Peck-Yin Chin, John E. Schjenken & Jeremy G. Thompson

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  1. Sarah A. Robertson
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  2. Peck-Yin Chin
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  3. John E. Schjenken
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  4. Jeremy G. Thompson
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Corresponding author

Correspondence to Sarah A. Robertson .

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Editors and Affiliations

  1. Hertford Building, Hull York Medical School University of Hull, Hull, United Kingdom

    Henry J. Leese

  2. St. Mary's Hospital Department of Reproductive Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

    Daniel R. Brison

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© 2015 Springer Science+Business Media New York

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Robertson, S., Chin, PY., Schjenken, J., Thompson, J. (2015). Female Tract Cytokines and Developmental Programming in Embryos. In: Leese, H., Brison, D. (eds) Cell Signaling During Mammalian Early Embryo Development. Advances in Experimental Medicine and Biology, vol 843. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2480-6_7

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