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A Practical Approach to Clinical and Research Biobanking

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Histopathology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1180))

Abstract

Powerful technologies critical to personalized medicine and targeted therapeutics require the analysis of carefully validated, procured, stored, and managed biospecimens. Reflecting advancements in biospecimen science, the National Cancer Institute and the International Society for Biological and Environmental Repositories are periodically publishing best practices that can guide the biobanker. The modern biobank will operate more like a clinical laboratory with formal accreditation, standard operating procedures, and quality assurance protocols. This chapter highlights practical issues of consent, procurement, storage, quality assurance, disbursement, funding, and space. Common topics of concern are discussed including the differences between clinical and research biospecimens, stabilization of biospecimens during procurement, optimal storage temperatures, and technical validation of biospecimen content and quality. With quickly expanding biospecimen needs and limited healthcare budgets, biobanks may need to be selective as to what is stored. Furthermore, a shift to room-temperature storage modalities where possible can reduce long-term space and fiscal requirements.

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Authors and Affiliations

  1. Translational Pathology Core Laboratory, Brain Tumor Translational Resource, Department of Pathology and Laboratory Medicine, Center for Health Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, 18-161 CHS, Los Angeles, CA, 90095, USA

    William H. Yong M.D.

  2. Translational Pathology Core Laboratory, Department of Pathology and Laboratory Medicine, Center for Health Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, 18-161 CHS, Los Angeles, CA, 90095, USA

    Sarah M. Dry M.D.

  3. Brain Tumor Translational Resource, Department of Pathology and Laboratory Medicine, Center for Health Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, 18-161 CHS, Los Angeles, CA, 90095, USA

    Maryam Shabihkhani M.D.

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  1. William H. Yong M.D.
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  2. Sarah M. Dry M.D.
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  3. Maryam Shabihkhani M.D.
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Correspondence to William H. Yong M.D. or Sarah M. Dry M.D. .

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Editors and Affiliations

  1. Department of Pathology, USC Keck School of Medicine, Los Angeles, California, USA

    Christina E. Day

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Yong, W.H., Dry, S.M., Shabihkhani, M. (2014). A Practical Approach to Clinical and Research Biobanking. In: Day, C. (eds) Histopathology. Methods in Molecular Biology, vol 1180. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1050-2_8

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  • DOI: https://doi.org/10.1007/978-1-4939-1050-2_8

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