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Src-Family Tyrosine Kinases in Oogenesis, Oocyte Maturation and Fertilization: An Evolutionary Perspective

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Posttranslational Protein Modifications in the Reproductive System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 759))

Abstract

The oocyte is a highly specialized cell poised to respond to fertilization with a unique set of actions needed to recognize and incorporate a single sperm, complete meiosis, reprogram maternal and paternal genomes and assemble them into a unique zygotic genome, and finally initiate the mitotic cell cycle. Oocytes accomplish this diverse series of events through an array of signal transduction pathway components that include a characteristic collection of protein tyrosine kinases. The src-family protein kinases (SFKs) figure importantly in this signaling array and oocytes characteristically express certain SFKs at high levels to provide for the unique actions that the oocyte must perform. The SFKs typically exhibit a distinct pattern of subcellular localization in oocytes and perform critical functions in different subcellular compartments at different steps during oocyte maturation and fertilization. While many aspects of SFK signaling are conserved among oocytes from different species, significant differences exist in the extent to which src-family-mediated pathways are used by oocytes from species that fertilize externally vs those which are fertilized internally. The observation that several oocyte functions which require SFK signaling appear to represent common points of failure during assisted reproductive techniques in humans, highlights the importance of these signaling pathways for human reproductive health.

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Acknowledgements

The field of PTK signaling during fertilization benefitted significantly from the contributions of Dr. David L. Garbers who provided important inspiration to this author as well as many others.

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  1. Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA

    William H. Kinsey

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Correspondence to William H. Kinsey .

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  1. Division of Animal Sciences, and Departments of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, Missouri, USA

    Peter Sutovsky

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Kinsey, W.H. (2014). Src-Family Tyrosine Kinases in Oogenesis, Oocyte Maturation and Fertilization: An Evolutionary Perspective. In: Sutovsky, P. (eds) Posttranslational Protein Modifications in the Reproductive System. Advances in Experimental Medicine and Biology, vol 759. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0817-2_3

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