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Anti-Viral Tetris: Modulation of the Innate Anti-Viral Immune Response by A20

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The Multiple Therapeutic Targets of A20

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 809))

Abstract

The A20 protein has emerged as an important negative regulator of Toll like receptor (TLR) and retinoic acid-inducible gene 1 (RIG-I)-mediated anti-viral signaling. A20 functions both as a RING-type E3 ubiquitin ligase and as a de-ubiquitinating enzyme. Nuclear factor kappa B (NF-κB) and interferon regulatory factor (IRF) pathways are targeted by A20 through mechanisms that appear to be both overlapping and distinct, resulting in the downregulation of interferon α/β (IfNα/β) production. This review specifically details the impact of A20 on the cytosolic RIG-I/MDA5 pathway, a process that is less understood than that of NF-κB but is essential for the regulation of the innate immune response to viral infection.

These authors equally contributed to the manuscript.

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Authors and Affiliations

  1. Lady Davis Institute - Jewish General Hospital, Departments of Microbiology & Immunology, McGill University, Montreal, Canada

    Meztli Arguello, Suzanne Paz & John Hiscott

  2. Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Christiane Ferran & Herwig P. Moll

  3. Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, USA

    John Hiscott

Authors
  1. Meztli Arguello
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  2. Suzanne Paz
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  3. Christiane Ferran
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  4. Herwig P. Moll
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  5. John Hiscott
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Correspondence to John Hiscott .

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Editors and Affiliations

  1. Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, Boston, Massachusetts, USA

    Christiane Ferran MD, PhD

  2. The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Christiane Ferran MD, PhD

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Arguello, M., Paz, S., Ferran, C., Moll, H.P., Hiscott, J. (2014). Anti-Viral Tetris: Modulation of the Innate Anti-Viral Immune Response by A20. In: Ferran, C. (eds) The Multiple Therapeutic Targets of A20. Advances in Experimental Medicine and Biology, vol 809. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0398-6_4

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