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The Nuclear Envelope and Cancer: A Diagnostic Perspective and Historical Overview

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Cancer Biology and the Nuclear Envelope

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 773))

Abstract

Cancer has been diagnosed for millennia, but its cellular nature only began to be understood in the mid-nineteenth century when advances in microscopy allowed detailed specimen observations. It was soon noted that cancer cells often possessed nuclei that were altered in size and/or shape. This became an important criterion for cancer diagnosis that continues to be used today. The mechanisms linking nuclear abnormalities and cancer only started to be understood in the second half of the twentieth century, with the discovery of nuclear lamina composition differences in cancer cells compared to normal cells. The nuclear envelope, rather than providing a mere physical barrier between the genetic material in the nucleus and the cytoplasm, is a very important functional hub for many cellular processes. In this review we give an overview of the links between cancer biology and nuclear envelope, from the early days of microscopy until the present day’s understanding of some of the molecular mechanisms behind those links.

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Abbreviations

H&E:

Hematoxylin and eosin

NET:

Nuclear envelope transmembrane protein

NPC:

Nuclear pore complex

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Acknowledgments

Work in the Schirmer lab is supported by Wellcome Trust Senior Research Fellowship 095209.

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Authors and Affiliations

  1. Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Building, Room 5.21, Edinburgh, EH9 3JR, UK

    Jose I. de las Heras

  2. Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Building, Room 5.22, Edinburgh, EH9 3JR, UK

    Eric C. Schirmer

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  1. Jose I. de las Heras
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  2. Eric C. Schirmer
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Correspondence to Jose I. de las Heras .

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  1. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Eric C. Schirmer

  2. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Jose I. de las Heras

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© 2014 Springer Science+Business Media New York

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de las Heras, J.I., Schirmer, E.C. (2014). The Nuclear Envelope and Cancer: A Diagnostic Perspective and Historical Overview. In: Schirmer, E., de las Heras, J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8032-8_1

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