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Emergent Behaviors in Cell Mechanics

  • Chapter
Structure-Based Mechanics of Tissues and Organs

Abstract

Cells and therefore tissues ordinarily experience some form of mechanical stimulation as they are often in mechanically diverse and dynamic environments. As a result we have learned that cells have the astounding ability to sense and respond to their environment. This seemingly innate behavior of cells has intrigued many researchers in the field of cell mechanics for decades and compelled efforts aimed at characterizing its behaviors and underlying mechanisms. While many techniques exist, in the context of this chapter, novel techniques we have developed and implemented will be examined as well as new emergent behaviors we have discovered. The behaviors that will be discussed have relevance in various areas of pathology and physiology including collective cell migration and cancer metastasis.

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Authors and Affiliations

  1. Program in Molecular and Integrative Physiological Sciences, School of Public Health, Harvard University, Boston, MA, 02115, USA

    Robert L. Steward Jr., Sonia R. Rosner & Jeffrey J. Fredberg

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  1. Robert L. Steward Jr.
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  2. Sonia R. Rosner
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  3. Jeffrey J. Fredberg
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Correspondence to Jeffrey J. Fredberg .

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  1. California Medical Innovations Institute , INDIANAPOLIS, Indiana, USA

    Ghassan S. Kassab

  2. Institute for Computational Engineering, The University of Texas at Austin Institute for Computational Engineering, PITTSBURGH, Pennsylvania, USA

    Michael S. Sacks

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Steward, R.L., Rosner, S.R., Fredberg, J.J. (2016). Emergent Behaviors in Cell Mechanics. In: Kassab, G., Sacks, M. (eds) Structure-Based Mechanics of Tissues and Organs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7630-7_3

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