Abstract
5-lipoxygenase (5-LO) metabolites have complex effects on bone cells. We have found that the leukotrine LTB4 and the peptido leukotrienes stimulate osteoclast formation in vitro and in vivo, and are likely involved in the generation of active osteoclast-like cells in giant cell tumors of bone. Recent preliminary observation in mice lacking the gene for 5-LO have not as yet demonstrated any effect on osteoclast function, but these mice have increased cortical bone, suggesting that 5-LO is a negative regulator of bone formation. 5-LO metabolites thus have unique effects on bone cell function, and clarifying their role may be important for the understanding of physiological as well as pathological bone remodeling.
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Bonewald, L.F., Flynn, M., Qiao, M., Dallas, M.R., Mundy, G.R., Boyce, B.F. (1997). Mice Lacking 5-Lipoxygenase Have Increased Cortical Bone Thickness. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_63
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_63
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