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The Role of Retinoids in Developmental Mechanisms in Embryos

  • Chapter
Fat-Soluble Vitamins

Part of the book series: Subcellular Biochemistry ((SCBI,volume 30))

Abstract

It has been known since the 1920s that the appropriate level of vitamin A (retinoids) in the maternal diet is vital for the development of the embryo (Kalter and Warkany, 1959). Both too little or too much vitamin A results in characteristic defects appearing in the embryo: defects in the central nervous system, various structures of the head and neck, the heart, the limb, and the urogenital system. These studies thus revealed that excess vitamin A was teratogenic and harmful to embryos and the usual interpretation of its effects was that it was causing cell death or an inhibition of development.

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Authors and Affiliations

  1. Developmental Biology Research Centre, King’s College London, London, WC2B 5RL, England

    Malcolm Maden

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  1. Malcolm Maden
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  1. King’s College London, University of London, London, UK

    Peter J. Quinn

  2. Department of Environmental and Occupational Health, and Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Valerian E. Kagan

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Maden, M. (1998). The Role of Retinoids in Developmental Mechanisms in Embryos. In: Quinn, P.J., Kagan, V.E. (eds) Fat-Soluble Vitamins. Subcellular Biochemistry, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1789-8_4

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  • DOI: https://doi.org/10.1007/978-1-4899-1789-8_4

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