Abstract
The mechanisms evaluated in animals as being responsible for cocaine associated hepatotoxicity are presented. The importance of the P-450 enzyme system in cocaine associated hepatotoxicity is emphasized. Moreover, the putative critical role of free radicals in such injury is discussed. Finally, the growing literature on clinical cases of cocaine hepatotoxicity is reviewed.
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References
Abelson HI, Miller JD: A decade of trends in cocaine use in the household population. Natl Inst Drug Abuse Res Morwgr 61:35–49, 1985.
Fishburn PM: National Survey on Drug Abuse, Main Findings 1979, DHHS publication no. ADM 80-976. Rockville, MD, NIDA, 1980.
Crebler LL, Mark H: Medical complications of cocaine abuse. N Engl J Med 315:1495–1500, 1986.
Marks V, Chappie PAL: Hepatic dysfunction in heroin and cocaine users. Br J Addict 62:189–195, 1967.
Ehrlich P: Studies in der cocain reihe. Dtsch Med Wochenschr 16:717–719, 1890.
Shuster L, Quimby F, Bates A, Thompson ML: Liver damage from cocaine in mice. Life Sci 20:1035–1042, 1977.
Thompson ML, Shuster L, Shaw K: Cocaine-induced hepatic necrosis in mice—the role of cocaine metabolism. Biochem Pharmacol 28:2389–2395, 1979.
Freeman RW, Harbison RD: Hepatic periportal necrosis induced by chronic administration of cocaine. Biochem Pharmacol 30:777–783, 1981.
Evans MA: Role of protein binding in cocaine-induced hepatic necrosis. J Pharmacol Exp Ther 224:73–79, 1983.
Kloss MW, Rosen GM, Rauckman EJ: Cocaine-mediated hepatotoxicity: a critical review. Biochem Pharmacol 33:169–173, 1984.
Donnelly DA, Boyer CS, Peterson DR, Ross D: Cocaine-induced biochemical changes and cytotoxicity in hepatocytes isolated from both mice and rats. Chem-Biol Interact 67:95–104, 1988.
Kanel GC, Cassidy W, Shuster L, Reynolds TB: Cocaine-induced liver cell injury: comparison of morphological features in man and in experimental models. Hepatology 11:646–651, 1990.
Thompson ML, Shuster L, Casey E: Sex and strain differences in response to cocaine. Biochem Pharmacol 33:1299–1307, 1984.
Smith AC, Freeman RW, Harbison RD: Ethanol enhancement of cocaine-induced hepatotoxicity. Biochem Pharmacol 30:453–458, 1981.
Stewart DJ, Inaba T, Lucassen M, Kalow W: Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases. Clin Pharmacol Ther 25:464–468, 1979.
Charkoudian JC, Shuster L: Electrochemistry of norcocaine nitroxide and related compounds: implications for cocaine hepatotoxicity. Biochem Biophys Res Commun 130:1044–1051, 1985.
Rauckman EJ, Rosen GM, Cavagnaro J: Norcocaine nitroxide: a potential hepatotoxic metabolite of cocaine. Mol Pharmacol 21:458–463, 1982.
Peterson FJ, Knodell RG, Lindemann NJ, Steele NM: Prevention of acetaminophen and cocaine hepatotoxicity in mice by cimetidine treatment. Gastroenterology 85:122–129, 1983.
James RC, Schiefer MA, Roberts SM, Harbison RD: Antagonism of cocaine-induced hepatotoxicity by the a adrenergic antagonists phentolamine and yohimbine. J Pharmacol Exp Ther 242:726–732, 1987.
Perino LE, Warren GH, Levine JS: Cocaine-induced hepatotoxicity in humans. Gastroenterology 93:176–180, 1987.
Wanless IR, Dore S, Gopinath N, Tan J, Cameron R, Heathcote EJ, Blendis LM, Levy G: Histopathology of cocaine hepatotoxicity. Report of four patients. Gastroenterology 98:497–501, 1990.
Silva MO, Roth D, Reddy KR, Fernandex JA, Albores-Saavedra J, Schiff ER: Hepatic dysfunction accompanying acute cocaine intoxication. J Hepatol 12:312–315, 1991.
Comeer GM, Mittal MK, Donelson SS, Lee T-P: Cluster of fulminant hepatitis B in crack users. Am J Gastroenterol 86:331–334, 1991.
Kothur R, Marsh F, Posner G: Liver function tests in non-parenteral cocaine users. Arch Intern Med 151:1126–1128, 1991.
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© 1992 Springer Science+Business Media New York
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Van Thiel, D.H., Perper, J.A. (1992). Hepatotoxicity Associated with Cocaine Abuse. In: Galanter, M. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1648-8_16
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DOI: https://doi.org/10.1007/978-1-4899-1648-8_16
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