Abstract
Coronaviruses are frequently claimed to have a characteristic morphology, including the possession of a “club-shaped” surface projection or spike (S) glycoprotein. However, in common with other aspects of the coronaviruses, the group exhibits variation with respect to the shape, size, and distribution of the S protein on the virion surface. Davies and Macnaughton (1979) described the spikes of infectious bronchitis virus (IBV) and human coronavirus (HCV) 229E as being “tear-drop” shaped and widely spaced, whereas those of murine hepatitis virus (MHV) type 3 were mostly “cone-shaped” and closely spaced, although in some MHV-3 preparations the spikes were more bulbous. Dimensions of S vary not only among the coronaviruses but also depending on the staining procedure; following potassium phosphotungstate staining all three viruses had spikes approximately 20 nm long and 10 nm wide at the bulbous end, except for the cone-shaped spikes of MHV, which had a diameter of only 5 nm (Davies and Macnaughton, 1979). The entire S protein has been observed after solubilization and purification (Sturman et al., 1980; Cavanagh, 1983c). The nonenvelope-associated S1 subunit of the IBV S protein can become detached from the virion (Stern and Sefton, 1982a; Cavanagh and Davis, 1986).
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Keywords
- Infectious Bronchitis Virus
- Mouse Hepatitis Virus
- Spike Protein
- Infectious Bronchitis Virus Strain
- Transmissible Gastroenteritis Virus
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
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Cavanagh, D. (1995). The Coronavirus Surface Glycoprotein. In: Siddell, S.G. (eds) The Coronaviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1531-3_5
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