Abstract
There is abundant evidence that taurine functions as an antioxidant in a variety of biological systems. Taurine reacts with HOCl, a potent oxidizing agent generated by activated neutrophils, to form the less toxic product, N-chlorotaurine (20). This reaction retards damage to ocular surfaces exposed to HOCl (13). Taurine protects cultured lymphoblastoid cells against iron-ascorbate or retinol-induced oxidant damage and enhances cell viability (16,17). Taurine supplementation protects the lung from oxidant-induced damage following exposure to ozone (2) or nitrogen dioxide (7). Taurine alone or in combination with niacin reduces pulmonary fibrosis following intratracheal installation of the oxidants, amiodarone (26) or bleomycin (27). Finally, taurine attenuates adriamycin-induced cardiotoxicity in perfused chick hearts by decreasing myocardial lipid peroxidation (9).
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References
Ayo, S.H., Radnick, R.A., Glass, W.A., II, Garoni, J.A., Rampt, E.R., Appling, D.R., and Kreisberg, J.I. 1991, Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium, Am.J.Physiol., 260:F185–F191.
Banks, M.A., Porter, D.W., Martin, W.G., and Castranova, V. 1990, Effects of in vitro ozone exposure on peroxidative damage, membrane leakage, and taurine content of rat alveolar macrophages, Toxicol.Appl. Pharmacol., 105:55–65.
Baynes, J.W. 1991, Role of oxidative stress in development of complications in diabetes, Diabetes, 40:405–412.
Diamond, J.R., Bonventre, J.V., and Karnovsky, M.J. 1986, A role for oxygen free radicals in aminonucleoside nephrosis, Kidney Int., 29:478–483.
Endreffy, E., Turi, S., Laszik, Z., Bereczki, C., and Kasa, K. 1991, The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis, Pediatr.Nephrol., 5:312–317.
Ginevri, F., Gusmano, R., Oleggini, R., Acerbo, S., Bertelli, R., Perfumo, F., Cercignani, G., Allegrini, S., D’Allegri, F., and Ghiggeri, G. 1990, Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis, Clin.Sci., 78:283–293.
Gordon, R.E., Shaker, A.A., and Solano, D.F. 1986, Taurine protects hamster bronchioles from acute NO2-induced alterations, Am.J.Pathol., 125:585–600.
Grond, J., Weening, J.J., and Elema, J.D. 1984, Glomerular sclerosis in nephrotic rats: comparison of the long-term effects of adriamycin and aminonucleoside, Lab.Invest., 51:277–284.
Hamaguchi, T., Azuma, J., Harada, H., Takahashi, K., Kishimoto, S., and Schaffer, S.W. 1989, Protective effect of taurine against doxorubicin-induced cardiotoxicity in perfused chick hearts, Pharmacol.Res., 21:729–734.
Lorenzi, M. 1992, Glucose toxicity in the vascular complications of diabetes: the cellular perspective, Diab.Metab.Rev., 8:85–103.
Massey, K.D. and Burton, K.P. 1990, Free radical damage in neonatal rat cardiac myocyte cultures: effects of α-tocopherol, trolox and phytol, Free Radic.Biol.Med., 8:449–458.
Nahman, N.S., Jr., Leonhart, K.L., Cosio, F.G., and Hebert, C.L. 1992, Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells, Kidney Int., 41:396–402.
Nakamori, K., Koyama, I., Nakamura, T., Nemoto, M., Yoshida, T., Umeda, M., and Inoue, K. 1993, Quantitative evaluation of the effectiveness of taurine in protecting the ocular surface against oxidant, Chem.Pharm.Bull. (Tokyo), 41:335–338.
Ohkawa, H., Ohishi, N., and Yagi, K. 1979, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal.Biochem., 94:351–358.
Palier, M.S., Hoidal, J.R., and Ferris, T.F. 1984, Oxygen free radicals in ischemic acute renal failure in the rat, J.Clin.Invest., 74:1156–1164.
Pasantes-Morales, H., Wright, C.E., and Gaull, G.E. 1984, Protective effect of taurine, zinc and tocopherol on retinol-induced damage in human lymphoblastoid cells, J.Nutr., 114:2256–2261.
Pasantes-Morales, H., Wright, C.E., and Gaull, G.E. 1985, Taurine protection of lymphoblastoid cells from iron-ascorbate induced damage, Biochem.Pharmacol., 34:2205–2206.
Skolnik, E.Y., Yang, Z., Makita, Z., Radoff, S., Kirstein, M., and Vlassara, H. 1991, Human and rat mesangial cell receptors for glucose-modified proteins: Potential role in kidney tissue remodelling and diabetic nephropathy, J.Exp.Med., 174:931–939.
Thakur, V., Walker, P.D., and Shah, S.V. 1988, Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria, Kidney Int., 34:494–499.
Thomas, E.L., Grisham, M.B., Melton, D.F., and Jefferson, M.M. 1985, Evidence for a role of taurine in the in vitro oxidative toxicity of neutrophils toward erythrocytes, J.Biol.Chem., 260:3321–3329.
Trachtman, H., Del Pizzo, R., Futterweit, S., Levine, D., Rao, P.S., Valderrama, E., and Sturman, J.A. 1992, Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy, Am.J.Physiol.Renal.Fluid Electrolyte Physiol., 262:F117–F123.
Trachtman, H., Futterweit, S., and Bienkowski, R.S. 1993, Taurine prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells, Biochem.Biophys.Res.-Commun., 191:759–765.
Trachtman, H., Lu, P., and Sturman, J.A. 1993, Immunohistochemical localization of taurine in rat renal tissue: Studies in experimental disease states, J.Histochem.Cytochem., 41:1209–1216.
Trachtman, H., Wilson, D., and Rao, P.S. 1992, The role of oxygen free radicals in the development of chronic renal failure, Life Sci., 50:1877–1883.
Walker, P.D. and Shah, S.V. 1988, Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats, J.Clin.Invest., 81:334–341.
Wang, Q., Hollinger, M.A., and Giri, S.N. 1992, Attenuation of amiodarone-induced lung fibrosis and phospholipidosis in hamsters by taurine and/or niacin treatment, J.Pharmacol.Exp.Ther., 262:127–132.
Wang, Q., Hyde, D.M., and Giri, S.N. 1992, Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin, Lab.Invest., 67:234–242.
Wolf, G., Sharma, K., Chen, Y., Ericksen, M., and Ziyadeh, F.N. 1992, High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β, Kidney Int., 42:647–656.
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Trachtman, H., Sturman, J.A. (1994). Taurine and Experimental Kidney Disease. In: Huxtable, R.J., Michalk, D. (eds) Taurine in Health and Disease. Advances in Experimental Medicine and Biology, vol 359. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1471-2_16
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DOI: https://doi.org/10.1007/978-1-4899-1471-2_16
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