Abstract
Many neurological diseases are accompanied by increased protein concentrations in cerebrospinal fluid (CSF), described as a blood-CSF barrier dysfunction. There is still widespread belief in a model based on “leakage”, i.e. a morphological defect is necessary to explain the empirical data. In my contribution I will show with a mathematical treatment of a diffusion model that an increased molecular flux of proteins through a diffusion barrier is possible without any morphological changes if only the CSF flow rate is decreased.
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© 1995 Springer Science+Business Media New York
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Reiber, H. (1995). Biophysics of Protein Diffusion from Blood into CSF: The Modulation by CSF Flow Rate. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_22
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DOI: https://doi.org/10.1007/978-1-4899-1054-7_22
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