Abstract
Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulate various lineage-committed cells as well as early multipotential progenitors while interleukin 5 (IL-5) stimulates eosinophils and basophils1. These three cytokines induce similar intracellular signals and exhibit similar functions in their common target cells. Although primary amino acid sequences of IL-3, IL-5 and GM-CSF show no obvious homology, they consist of four α-helices and their gross tertiary structures are similar. Interestingly, binding of a human cytokine to its high affinity receptor is inhibited by another cytokine on their common target cells, e.g. high affinity IL-3 binding to its receptor is inhibited by GM-CSF and vice versa2.
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K. Arai, F. Lee, A. Miyajima, S. Miyatake, N. Arai, and T. Yokota, Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59: 783 (1990).
A.F. Lopez, M.V. Vadas, J.M. Woodcock, S.E. Milton, A. Lewis, M.J. Elliott, D. Gillis, R. Ireland, E. Olwell, and L.S. Park, Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. J. Biol. Chem.. 266: 24741 (1991).
A. Miyajima, A. L-F. Mui, T. Ogorochi, and K. Sakamaki, Receptors for granulocyte-macrophage colony-stimulating factor, interleukin 3 and interleukin 5. Blood. 82: 1960 (1993).
K. Sakamaki, I. Miyajima, T. Kitamura, and A. Miyajima, Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 11: 3541 (1992).
T. Satoh, M. Nakafuku, A. Miyajima, and Y. Kaziro, Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. Proc Natl Acad Sci USA. 88: 3314 (1991).
V. Duronio, M.J. Welham, S. Abraham, P. Dryden, and J.W. Schrader, p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein. Proc. Natl. Acad. Sci. USA.. 89: 1587 (1992).
N. Sato, K. Sakamaki, N. Terada, K. Arai, and A. Miyajima, Signal transduction by the high affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for differentiation. EMBO J.. 12: 4181 (1993).
E. J. Lowenstein, R.J. Daly, A.G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E.Y. Skolnik, S.D. Bar, and J. Schlessinger, The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 70: 431 (1992).
G. Pelicci, L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson, and P.G. Pelicci, A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 70: 93 (1992).
E. Gulbins, K. Coggeshall, G. Baier, S. Katzav, P. Burn, and A. Altman, Tyrosine kinase-stimulated guanine nucleotide exchange activity of vav in T cell activation. Science. 260: 822 (1993).
A. Mui, R. Cutler, M. Alai, X. Bustelo, M. Barbacid, and G Krystal, Steel factor and interleukin-3 stimulate the tyrosine phosphorylation of p95vav in hemopoietic cell lines. Exp Hematol. 20: 752a (1992).
L. Van Aelst, M. Barr, S. Marcus, A. Polverino, and M. Wigler, Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. USA. 90: 6213 (1993).
E. Nishida and Y. Gotoh, The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci. 18: 128 (1993).
J. Blenis, J. Chung, E. Erikson, D.A. Alcorta, and R.L. Erikson, Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. Cell Growth Diff.. 2: 279 (1991).
L.M. Wang, A.D. Keegan, W.E. Paul, M.A. Heidaran, J.S. Gutkind, and J.H. Pierce, L-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J. 11: 4899 (1992).
J. Domen, N.M.T. van der Lugt, P. Laird, C.J.M. Saris, A.R. Clarke, M.L. Hooper, and A. Berns, Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. Blood. 82: 1445 (1993).
H.-M. Wang, M. Collins, K. Arai, and A. Miyajima, EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor. EMBO J. 8: 3677 (1989).
S. Watanabe, A. L. Mui, A. Muto, J.X. Chen, K. Hayashida, T. Yokota, A. Miyajima, and K. Arai, Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH3T3 cells: Comparison with signaling in BA/F3 pro-B cells. Mol Cell Biol. 13: 1440 (1993).
X-Y. Fu, A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s). Cell. 70: 323 (1992).
L.S. Artgetsinger, G.S. Cambell, X. Yang, B.A. Witthuhn, O. Silvennoinen, J.N. Ihle, and C. Carter-Su, Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell. 74: 237 (1993).
B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and J.N. Ihle, JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 74: 227 (1993).
O. Silvennoinen, B.A. Witthuhn, F.W. Quelle, J.L. Cleveland, T. Yi, and J.N. Ihle, Structure of the murine JAK2 protein tyrosine kinase and its role in IL-3 signal transduction. Proc. Natl. Acad. Sci. USA.. 90: 8429 (1993).
J. Schlessinger and A. Ullrich: Growth factor signaling by receptor tyrosine kinases. Neuron. 9: 383 (1992).
S. Davis, T.H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, I.N. Y., and G.D. Yancopoulos, LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science. 260: 1805 (1993).
M. Murakami, M. Hibi, N. Nakagawa, T. Nakagawa, K. Yasukawa, K. Yamanishi, T. Taga, and T. Kishimoto, IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 260: 1808 (1993).
N. Stahl, T.G. Boulton, T. Farruggella, N.Y. Ip, S. Davis, B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, G. Barbieri, S. Pellegrini, J.N. Ihle, and G.D. Yancopoulos, Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components. Science. 263: 92 (1994).
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Mui, A. et al. (1994). Function of the Common β Subunit of the GM-CSF/IL-3/IL-5 Receptors. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_22
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DOI: https://doi.org/10.1007/978-1-4899-0987-9_22
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