Skip to main content

Protective Effect of Taurine against Reperfusion Injury in Cultured Rat Astrocytes

  • Chapter
Taurine 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 403))

Abstract

Astrocytes, the most abundant glial cells in the brain, are considered to have physiological and pathological roles in neuronal activities. Goldman et al. 3 and we11 independently reported that the Na+/Ca2+ exchanger is present in cultured astrocytes. The Na+/Ca2+ exchanger plays an important role in regulation of [Ca2+]i, the antiporter being bi-directional: the forward mode causes Ca2+ efflux, and the reverse mode causes Ca2+ influx.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Asano, S., Matsuda, T., Takuma, K., Kim, H.S., Sato, T., Nishikawa, T., and Baba, A. 1995, Nitroprusside and cyclic GMP stimulate Na+-Ca2+ exchange activity in neuronal preparations and cultured rat astrocytes, J.Neurochem. 64:2437–2441.

    Article  CAS  Google Scholar 

  2. Bredt, D.S. and Snyder, S.H. 1990, Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme, Pwc.Natl.Acad.Sci. 87:682–685.

    Article  CAS  Google Scholar 

  3. Goldman, W.F., Yarowsky, P.J., Juhaszova, M., Krueger, B.K., and Blaustein, M.P. 1994, Sodium/calcium exchange in rat cortical astrocytes, J.Neurosci. 14:5834–5843.

    CAS  Google Scholar 

  4. Harris, R.J., Symon, L., Branston, N.M., and Bayhan, M. 1981, Changes in extracellular calcium activity in cerebral ischsiemia, J.Cereb.Blood.Flow.Metabol. 1:203–209.

    Article  CAS  Google Scholar 

  5. Koyama, Y., Ishibashi, T., Tanaka, K., and Baba, A. 1994, L-Glutamate-stimulated taurine release from rat cerebral cultured astrocytes, J.Neurosci.Res. 38:75–80.

    Article  CAS  Google Scholar 

  6. Kramer, J.H., Chovan, J.P., and Schaffer, S.W. 1981, Effect of taurine on calcium paradox and ischemic heart failure, Am.J.Physiol. 240:H238–H246.

    CAS  Google Scholar 

  7. Matsuda, T., Gemba, T., Baba, A., and Iwata, H. 1989, Inhibition by taurine of Na+-Ca2+ exchange in sarcolemmal membrane vesicles from bovine and guinea pig hearts, Comp.Biochem.Physiol. 94C:335–339.

    CAS  Google Scholar 

  8. Matsuda, T., Murata, Y., Kawamura, N., Hayashi, M., Tamada, K., Takuma, K., Maeda, S., and Baba, A. 1993, Selective induction of α1 isozyme of (Na+ + K+)-ATPase by insulin/insuin-like growth factor-I in cultured rat astrocytes, Arch.Biochem.Biophys. 307:175–182.

    Article  CAS  Google Scholar 

  9. Matsuda, T., Takuma, K., Nishiguchi, E., Asano, S., Hashimoto, H., Azuma, J. and Baba, A. 1996, Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes, Eur.J.Neurosci. in press.

    Google Scholar 

  10. Takuma, K., Matsuda, T., Asano, S., and Baba, A. 1995, Intracellular ascorbic acid inhibits the Na+-Ca2+ exchanger in cultured rat astrocytes, J.Neurochem. 64:1536–1540.

    Article  CAS  Google Scholar 

  11. Takuma, K., Matsuda, T., Hashimoto, H., Asano, S., and Baba, A. 1994, Cultured rat astrocytes possess Na+-Ca2+exchanger, Glia, 12:336–342.

    Article  CAS  Google Scholar 

  12. Young, W., Yen, V., and Blight, A. 1982, Extracellular calcium activity in experimental spinal cord contusion, Brain Res. 253:115–130.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Matsuda, T., Takuma, K., Kishida, Y., Azuma, J., Baba, A. (1996). Protective Effect of Taurine against Reperfusion Injury in Cultured Rat Astrocytes. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_53

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0182-8_53

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0184-2

  • Online ISBN: 978-1-4899-0182-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics