Abstract
Taurine increases Cl- conductance across neuronal membranes, leading to changes in neuronal excitability12, 25. However, the exact mechanisms of these taurine effects are not yet known. For instance, taurine may act via metabotropic receptors coupled to a second-messenger system or via ionotropic receptors gating ion channels. Indeed, taurine has been shown to interfere with the binding of GABA to both ionotropic GABAA 22 and metabotropic GABAB 19 receptors and to displace strychnine from ionotropic glycine receptors17. Moreover, the existence of a specific taurine receptor is not excluded18, 20, 27.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Banderali, U., and Roy, G., 1992, Anion channels for amino acids in MDCK cells, Am. J. Physiol., 263: C1200–C1207.
Cull-Candy, S.G., and Ogden, D.C., 1985, Ion channels activated by L-glutamate and GABA in cultured cerebellar neurons of the rat, Proc. R. Soc. Lond. B, 224: 367–373.
Dubin, A.E., and Dionne, V.E., 1993, Modulation of Cl-, K+, and nonselective cation conductances by taurine in olfactory receptor neurons of the mudpuppy Necturus maculosus, J. Gen. Physiol, 101: 469–485.
Frederickson, R.C.A., Neuss, M., Morzorati, S.L., and McBride, W.J., 1978, A comparison of the inhibitory effects of taurine and GABA on identified Purkinje cells and other neurons in the cerebellar cortex of the rat, Brain Res., 145: 117–126.
Galarreta, M., Bustamante, J., Martin del Rio, R., and Solis, J.M., 1994, Taurine induces a long lasting increase of synaptic transmission in rat hippocampal slices, Soc. Neurosci. Abstr., 20: 1342.
Galdzicki, Z., Lin, F., Moran, O., Novelli, A., Puia, G., and Sciancalepore, M., 1991, Development of voltage-dependent ionic currents in rat cerebellar granule cells grown in primary culture, Int. J. Neurosci., 56: 193–200.
Hamill, O.P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F.J., 1981, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pflügers Arch., 391: 85–100.
Häusser, M. A., Yung, W.H., and Lacey, M.G., 1992, Taurine and glycine activate the same Cl- conductance in substantia nigra dopamine neurones, Brain Res., 571: 103–108.
Holopainen, I., Malminen, O., and Kontro, P., 1987, Sodium-dependent high-affinity uptake of taurine in cultured cerebellar granule cells and astrocytes, J. Neurosci. Res., 18: 479–483.
Horikoshi, T., Asanuma, A., Yanagisawa, K., Anzai, K., and Goto, S., 1988, Taurine and β-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA, Mol. Brain Res., 4:97–105.
Huck, S., and Lux, H.D., 1987, Patch-clamp study of ion channels activated by GABA and glycine in cultured cerebellar neurons of the mouse, Neurosci. Lett., 79: 103–107.
Huxtable, R.J., 1989, Taurine in the central nervous system and the mammalian actions of taurine, Prog. Neurobiol., 32:471–533.
Inomata, H., Nabekura, J., and Akaike, N., 1993, Suppression of taurine response in acutely dissociated substantia nigra neurons by intracellular cyclic AMP, Brain Res., 615: 347–350.
Jalonen, T., Johansson, S., Holopainen, I., Oja S.S., and Århem P., 1990, Single-channel and whole-cell currents in rat cerebellar granule cells, Brain Res., 535: 33–38.
Jalonen, T., Kivelä, A., Johansson, S., Holopainen, I., Oja, S.S., and Ärhem, P., 1990, Electrophysiological properties of cerebellar granule cells in culture, Abstracts of the 5th Finnish Neurochemistry Meeting, Espoo, p. 20.
Kilic, G., Moran, O., and Cherubini, E., 1993, Currents activated by GABA and their modulation by Zn2+ in cerebellar granule cells in culture, Eur. J. Neurosci., 5: 65–72.
Kontro, P., and Oja, S.S., 1987, Glycinergic systems in the brain stem of developing and adult mice: effects of taurine, Int. J. Dev. Neurosci., 5: 461–470.
Kontro, P., and Oja, S.S., 1987, Co-operativity in sodium-independent taurine binding to brain membranes in the mouse, Neuroscience, 23: 567–570.
Kontro, P., and Oja, S.S., 1990, Interactions of taurine with GABAB binding sites in mouse brain, Neuropharmacology, 29: 243–247.
Kudo, Y., Akiyoshi, E., and Akagi, H., 1988, Identification of two taurine receptor subtypes on the primary afferent terminal of frog spinal cord, Br. J. Pharmacol, 94: 1051–1056.
Linne, M.-L., Oja, S.S., and Jalonen, T.O., 1995, The effects of taurine on single ion channel activity in rat cerebellar granule cells, Biophys. J., 68: A379.
Malminen, O., and Kontro, P., 1987, Actions of taurine on the GABA-benzodiazepine receptor complex solubilized from rat brain, Neurochem. Int., 11: 113–117.
Mathers, D.A., 1993, Effects of benzothiadiazine TAG on channel activation at mammalian glycine receptors, Neurosci. Lett., 149: 23–26.
Mathers, D.A., Grewal, A., and Wang, Y., 1989, Membrane channels activated by taurine in cultured mouse spinal cord neurons, Neurosci. Lett, 98: 229–233.
Oja, S.S., Korpi, E.R., and Saransaari, P., 1990, Modification of chloride flux across brain membranes by inhibitory amino acids in developing and adult mice, Neurochem. Res., 15: 797–804.
Wahl, P., Elster, L., and Schousboe, A., 1994, Identification and function of glycine receptors in cultured cerebellar granule cells, J. Neurochem., 62: 2457–2463.
Wu, J.-Y., Tang, X.W., and Tsai, W.H., 1992, Taurine receptor: kinetic analysis and pharmacological studies, Adv. Exp. Med. Biol., 315: 263–268.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Linne, ML., Jalonen, T.O., Saransaari, P., Oja, S.S. (1996). Taurine-Induced Single-Channel Currents in Cultured Rat Cerebellar Granule Cells. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_49
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0182-8_49
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0184-2
Online ISBN: 978-1-4899-0182-8
eBook Packages: Springer Book Archive