Abstract
Platelet-activating factor (PAF) is known to be synthesized by either a remodeling or de novo pathway. The enzymes responsible have been extensively studied by a number of laboratories. All evidence indicates the remodeling route is activated during inflammation and other hypersensitivity responses, whereas the de novo pathway is thought to be the source of PAF required for physiological functions. This article provides an update of what is currently known adout the enzymatic systems that generate PAF as well as some preliminary findings we have obtained using potential inhibitors of the specific enzymes involved. Recent progress from our laboratory toward understanding the role of the CoA-independent and Co-A dependent transacylases in the formation of lyso-PAF and PAF is summarized.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Snyder, F. (1995) Biochim. Biophys. Acta 1254, 231–249.
Snyder, F. (1995) Biochem. J. 305, 689–705.
Wykle, R.L., Malone, B., and Snyder, F. (1980) J. Biol. Chem. 255, 10256–10260.
Uemura, Y., Lee, T-c., and Snyder, F. (1991) J. Biol. Chem. 266, 8268–8272.
Blank, M.L., Smith, Z.L., Fitzgerald, V., and Snyder, F. (1995) Biochim. Biophys. Acta 1254, 295–301.
Blank, M.L., Fitzgerald, V., Smith, Z.L., and Snyder, F. (1995) Biochem. Biophys. Res. Commun. 210, 1052–1058.
Lee, T-c., Malone, B., and Snyder, F. (1986) J. Biol. Chem. 261, 5373–5377.
Lee, T-c., Malone, B., and Snyder, F. (1988) J. Biol. Chem. 263, 1755–1760, 1988.
Woodard, D.S., Lee, T-c., and Snyder, F. (1987) J. Biol. Chem. 262, 2520–2527.
Nieto, M.L., Venable, M.E., Bauldry, S.A., Greene, D.G., Kennedy, M., Bass, D.A., and Wykle, R.L. (1991) J. Biol. Chem. 266, 18699–18706.
Sugiura, T., Fukuda, T. Masuzawa, Y., and Waku, K. (1990) Biochim. Biophys. Acta 1047, 223–232.
Venable, M.E., Nieto, M.L., Schmitt, J.D., and Wykle, R.L. (1991) J. Biol. Chem. 266, 18691–18698.
Winkler, J.D., Sung, C.-M., Hubbard, W.C., and Chilton, F.H. (1992) Biochem. Pharmacol. 44, 2055–2066.
Colard, O., Bidault, J., Berton, M., and Ninio, E. (1993) Eur. J. Biochem. 216, 835–840.
MacDonald, J.I.S. and Sprecher, H. (1991) Biochim. Biophys. Acta 1084, 105–121.
Snyder, F., Lee, T-c., and Blank, M.L. (1992) Prog. Lipid Res. 31, 65–86.
Irvine, R.F. and Dawson, R.M.C. (1979) Biochem. Biophys. Res. Commun. 91, 1399–1405.
Sugiura, T., Kudo, N., Ojima, T., Mabuchi-Itoh, K., Yamashita, A., and Waku, K. (1995) Biochim. Biophys. Acta 1255, 167–176.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Snyder, F., Fitzgerald, V., Blank, M.L. (1996). Biosynthesis of Platelet-Activating Factor and Enzyme Inhibitors. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_2
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0179-8_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0181-1
Online ISBN: 978-1-4899-0179-8
eBook Packages: Springer Book Archive