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The Crystal Structure of Cytochrome P-450cam

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Cytochrome P-450

Abstract

From the preceding chapters it is clear that a high-resolution crystal structure of P-450 is very desirable and that the obvious candidate for crystallographic studies is P-450cam. Indeed, some of the earliest studies on P-450cam resulted in its crystallization by Yu et al. in 1974.1 However, these crystals, designated orthorhombic I,2 were unsuitable for X-ray diffraction studies and it was not until 1982 that the first X-ray-quality crystals were reported.2 Gunsalus’s group and especially the efforts of G. C. Wagner were instrumental in reaching this milestone.

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Authors and Affiliations

  1. Genex Corporation, Gaithersburg, Maryland, 20877, USA

    Thomas L. Poulos

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  1. Thomas L. Poulos
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Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, 94143, San Francisco, California, USA

    Paul R. Ortiz de Montellano

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Poulos, T.L. (1986). The Crystal Structure of Cytochrome P-450cam . In: de Montellano, P.R.O. (eds) Cytochrome P-450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9939-2_13

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  • DOI: https://doi.org/10.1007/978-1-4757-9939-2_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9941-5

  • Online ISBN: 978-1-4757-9939-2

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