Abstract
Metabolic maps of the early 1950s showed enzymes interacting only with their immediate substrates, products and coenzymes. How a cell resisted marked changes in its flux rates in response to changes in concentrations of external substrates (even when none of its enzymes was saturated), or responded to changes in the concentrations of external effectors (e.g. hormones) was a mystery.
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Porteous, J.W. (1990). Control Analysis: a Theory that Works. In: Cornish-Bowden, A., Cárdenas, M.L. (eds) Control of Metabolic Processes. NATO ASI Series, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9856-2_4
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