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Features and Functions of Human Microglia Cells

  • Chapter
Brain Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 429))

Abstract

Microglia represent a population of resident cells of the central nervous system (CNS) which have attracted much interest because of their multiple functions. Two principal forms of microglia have been described. “Ameboid” cells, also referred as gitter cells or reactive microglia, which appear during the embryonal period and after brain lesions, are morphologically similar to macrophages (Giulian and Baker, 1986; Giulian, 1987). The second form of microglia, the “ramified” cells (Ling, 1981), appear during the late postnatal period and persist through adult life (Murabe and Sano, 1983). Although the nature of the relationship between ameboid and ramified microglia is controversial, ramified microglia are generally viewed as functional quiescent microglia that lack monocytic properties, but acquire ameboid features and reactivity in the presence of tissue damage (del Rio Hortega, 1919; 1932; Oemichen, 1983).

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Authors and Affiliations

  1. Department of Cytomorphology, School of Medicine, Cagliari, Italy

    Fulvia Gremo M.D. (Professor), Valeria Sogos, Maria Grazia Ennas, Alessandra Meloni, Tiziana Persichini, Marco Colasanti & Giuliana Maria Lauro

  2. Department of Cell Biology, III University, Roma, Italy

    Fulvia Gremo M.D. (Professor), Valeria Sogos, Maria Grazia Ennas, Alessandra Meloni, Tiziana Persichini, Marco Colasanti & Giuliana Maria Lauro

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Editors and Affiliations

  1. University of Torino, Torino, Italy

    Guido Filogamo

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    Antonia Vernadakis

  3. University of Cagliari, Cagliari, Italy

    Fulvia Gremo

  4. Université Montpellier II, Montpellier, France

    Alain M. Privat

  5. University of California, Berkeley, California, USA

    Paola S. Timiras

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Gremo, F. et al. (1997). Features and Functions of Human Microglia Cells. In: Filogamo, G., Vernadakis, A., Gremo, F., Privat, A.M., Timiras, P.S. (eds) Brain Plasticity. Advances in Experimental Medicine and Biology, vol 429. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9551-6_6

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  • DOI: https://doi.org/10.1007/978-1-4757-9551-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9553-0

  • Online ISBN: 978-1-4757-9551-6

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