Summary
In this study we examined the sera from 42 randomly selected patients with RA. ANCA was demonstrated by indirect immunofluorescence on human granulocytes in 10 patients with active disease and in none of the patients with inactive disease. ELISA’s for the detection of specific antigens showed the presence of anti-myeloperoxidase in 3 patients, and anti-lactoferrin in 1 patient. The specificity of the remaining antibodies was unidentified. All 3 patients with antibodies to myeloperoxidase had vasculitis.
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References
Coremans, I.E.M.., Hagen, E.C.., Van de Woude, F. J., Daha, M.R., Van der Voort, E.A.M., Verweij, C.L., Kleiburg-van der Keur, C.L., Breedveld, F.C., 1992, Anti lactoferrin antibodies in patients with rheumatoid arthritis with vasculitis. Clin Rheum 11: 124.
Hagen, E.C., Ballieux, B.E.P.B., Daha, M.R., Van Es, L.A., Van der Woode, F.J., 1992, Fundamental and clinical aspects of anti-neutrophil cytoplasmic antibodies. Autoimmunity 11: 199–207.
Lucena-Fernandes, M.F., Dalpe, G., Dulhaime, N., Richard, C., Menard, H.A., 1991, ANCA in rheumatic diseases. (1990 ANCA Workshop).
Mulder, A.H., Horst, G., Van Leeuwen, M.A., Limburg, P.C., Kallenburg, C.G.M., 1992, Anti- neutrophil cytoplasmic antibodies in rheumatoid arthritis. Clin Rheum 11: 131.
Savage, C.O.S., Winnerals, C.G., Jones, S., Marshall, P.D., Lockwood, C.M., 1987, Prospective study of radio-immunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet i: 1389.
Savage, J.A., Gallicchio, M.C., Stockman, A., Cunningham, T.J., Rowdy, M.J., Georgiou, T., Davies, D. 1991, Anti-neutrophil cytoplasm antibodies in rheumatoid arthritis. Clin.Exp.Immunol 86: 92–98.
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© 1993 Springer Science+Business Media New York
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Charles, P.J., Maini, R.N. (1993). Antibodies to Neutrophil Cytoplasmic Antigens in Rheumatoid Arthritis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_62
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_62
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