Summary
The expression of cytokines that are potentially involved in the pathogenesis of vasculitis was studied in patients with primary systemic vasculitis (PSV). In extension of earlier reports, we detected an overexpression of transforming growth factor B (TGFB), interleukin 6 (IL6), and interleukin 8 (IL8), indicating that the whole cytokine cascade is activated to a significant extent in PSV.
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References
Burrows, L.J., Piper, P.J., Lindley, I.D., and Westwick, J., 1991, Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086, Ann.N. Y.Acad.Sci. 629: 422.
Gross, W.L., Csernok, E., and Schmitt, W.H., 1991, Antineutrophil cytoplasmic autoantibodies: Immunobiological aspects, Klin. Wochenschr. 69: 558.
Kekow, J., Wachsman, W., McCutchan, J.A., Cronin, M., Carson, D.A., and Lotz, M., 1990, Transforming growth factor ß and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection, ProcNatl.Acad.Sci. USA. 87: 8321.
Mrowietz, U., Sticherling, M., Mielke, V., Schröder, J.-M., and Christophers, E., 1991, Neutrophilactivating peptide 1/interleukin 8 mRNA expression and protein secretion by human monocytes: Effect of cyclosporin A, Cytokine3: 322.
Sheron, N. and Williams, R., 1992, IL-8 as a circulating cytokine: Induction by recombinant tumor necrosis factor-alpha, CIin.Exp.Immunol 89: 100.
Zhou, D., Munster, A., and Winchurch, R.A., 1991, Pathologic concentration of interleukin 6 inhibit T-cell responses via induction of activation of TGFB, FASEBJ. 5: 2582.
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© 1993 Springer Science+Business Media New York
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Kekow, J., Szymkowiak, C.H., Sticherling, M., Schröder, JM., Christophers, E., Gross, W.L. (1993). Pro- and Anti-Inflammatory Cytokines in Primary Systemic Vasculitis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_56
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_56
Publisher Name: Springer, Boston, MA
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