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Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor

  • Chapter
Steroid Hormone Receptor Systems

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 117))

Abstract

Since the original identification of cytoplasmic estrogen receptors (ER) in human breast cancer (1), rapid progress has been made towards linking presence of the receptor with endocrine responsiveness of the tumor. It is now known that the likelihood of a successful response to endocrine therapy is increased at least 10-fold in patients whose tumors are positive for ER (2). However, not all ER containing tumors respond, and this has led to the concept that ER are necessary but not sufficient markers of hormone dependence.

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Authors and Affiliations

  1. The University of Texas Health Science Center, San Antonio, Texas, 78284, USA

    Kathryn B. Horwitz & William L. McGuire

Authors
  1. Kathryn B. Horwitz
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  2. William L. McGuire
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Editor information

Editors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, USA

    Wendell W. Leavitt

  2. Baylor College of Medicine, Houston, Texas, USA

    James H. Clark

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© 1979 Springer Science+Business Media New York

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Horwitz, K.B., McGuire, W.L. (1979). Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor. In: Leavitt, W.W., Clark, J.H. (eds) Steroid Hormone Receptor Systems. Advances in Experimental Medicine and Biology, vol 117. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6589-2_5

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  • DOI: https://doi.org/10.1007/978-1-4757-6589-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6591-5

  • Online ISBN: 978-1-4757-6589-2

  • eBook Packages: Springer Book Archive

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