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Dibutyryl Cyclic AMP Treatment of Astrocytes in Primary Cultures as a Substitute for Normal Morphogenic and ‘Functiogenic’ Transmitter Signals

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Molecular Aspects of Development and Aging of the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 265))

Abstract

It has now become very well established that compounds which in the mature organism function as neurotransmitters may play a major developmental role as “morphogens” (Turing, 1952) during development (Lauder, 1988). In some cases this occurs in regions where the compound in question is not utilized as a transmitter in the mature animal, but in other cases a neurotransmitter seems to be a morphogen for specifically those cells which are destined to become its target cells. Such a system has also been known for a long time in the autonomic nervous system where, for example, innervation directly affects receptor clustering. There is good reason to believe that the same agents also have a differentiating effect on functional (biochemical and biophysical) parameters, i.e., also act as “functiogens”.

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Authors and Affiliations

  1. Department of Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N OWO, Canada

    Leif Hertz

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  1. Leif Hertz
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Editors and Affiliations

  1. The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Jean M. Lauder

  2. Institute of Biology, INSERM, Montpellier, France

    Alain Privat

  3. Southern Illinois University School of Medicine, Springfield, Illinois, USA

    Ezio Giacobini

  4. University of California, Berkeley, California, USA

    Paola S. Timiras

  5. University of Colorado School of Medicine, Denver, Colorado, USA

    Antonia Vernadakis

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Hertz, L. (1990). Dibutyryl Cyclic AMP Treatment of Astrocytes in Primary Cultures as a Substitute for Normal Morphogenic and ‘Functiogenic’ Transmitter Signals. In: Lauder, J.M., Privat, A., Giacobini, E., Timiras, P.S., Vernadakis, A. (eds) Molecular Aspects of Development and Aging of the Nervous System. Advances in Experimental Medicine and Biology, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5876-4_22

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  • DOI: https://doi.org/10.1007/978-1-4757-5876-4_22

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