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Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions

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Advances in Cardiovascular Engineering

Part of the book series: NATO ASI Series ((NSSA,volume 235))

Abstract

Perfusion models that allow exposure of artery subendothelium, collagen and other surfaces to non-anticoagulated blood (ex vivo models) or to anticoagulated blood (in vitro models) under well controlled experimental conditions have given much useful information about thrombotic mechanisms(1–15) This includes a better understanding of molecular mechanisms of platelet-surface adhesion(3,6,13,16–19), platelet-platelet interactioe(3,13,16,20–23), and the interplay between coagulation and platelet function in thrombus formation(4,12–14,22–27) However, the blood flow, and in particular the shear rate, plays an unambiguous role in these events(1–3,13,14,16.17,19,21–25,28,29).

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Authors and Affiliations

  1. Biotechnology Centre of Oslo, University of Oslo, P.O.Box 1125, 0317, Oslo, Norway

    Kjell S. Sakariassen, Helge E. Roald & José Aznar Salatti

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  1. Kjell S. Sakariassen
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  1. University of Miami, Coral Gables, Florida, USA

    Ned H. C. Hwang

  2. Department of Biomedical Engineering, Memphis State University, Memphis, Tennessee, 38152, USA

    Vincent T. Turitto  & Michael R. T. Yen  & 

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Sakariassen, K.S., Roald, H.E., Salatti, J.A. (1992). Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions. In: Hwang, N.H.C., Turitto, V.T., Yen, M.R.T. (eds) Advances in Cardiovascular Engineering. NATO ASI Series, vol 235. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4421-7_10

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