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The EGF Receptor Signaling System

A Model for Growth Factor Receptor Signaling

  • Chapter
Hormone Signaling

Part of the book series: Endocrine Updates ((ENDO,volume 17))

Abstract

The receptor for epidermal growth factor (EGF) and related ligands (EGFR; also referred to as HER and c-erbB 1) is expressed on cells of many lineages. Receptor binding by at least five genetically distinct ligands activates the intrinsic kinase resulting in EGFR tyrosyl-phosphorylating itself and numerous intermediary effector molecules, including closely-related c-erbB receptor family members. This action initiates a multitude of signaling pathways, some of which attenuate receptor signaling. The integrated biological responses to EGFR signaling include mitogenesis or apoptosis, enhanced cell motility, protein secretion, and differentiation or dedifferentiation; the outcome depends both on the proteomic complement of cell and other operative extracellular signals. Implicated in organ morphogenesis, maintenance and repair, upregulated EGFR signaling also correlates with a wide variety of tumors, especially at progression to invasion and metastasis. Thus, EGFR and its resultant signals are therapeutic targets in cancer and wound healing treatments.

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Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 15261, USA

    Alan Wells

  2. Pathology and Laboratory Services, Pittsburgh VAMC, Pittsburgh, PA, 15261, USA

    Alan Wells

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  1. Inserm Unit 344, Molecular Endocrinology, Faculty of Medicine Necker, Paris, France

    Vincent Goffin PhD  & Paul A. Kelly PhD  & 

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Wells, A. (2002). The EGF Receptor Signaling System. In: Goffin, V., Kelly, P.A. (eds) Hormone Signaling. Endocrine Updates, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3600-7_4

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  • DOI: https://doi.org/10.1007/978-1-4757-3600-7_4

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