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New Methods for the Analysis of Insulin Kinetics in Vivo: Insulin Secretion, Degradation, Systemic Dynamics and Hepatic Extraction

  • Chapter
Comparison of Type I and Type II Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 189))

Abstract

Glucose is a metabolite which is subject to a high degree of control. It is a principal substrate for the metabolic activity of the central nervous system, but its availability from exogenous sources is sporadic. This has led to the development of hormone systems which titrate the distribution of energy-rich substrates among different tissues in a very precise manner. That these hormone systems are efficient is manifest in the minimal perturbations seen, for example, in plasma glucose concentrations after the ingestion of a carbohydrate containing meal.

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Authors and Affiliations

  1. Dept. of Medicine, McGill University, Montreal, Quebec, Canada

    J. Radziuk

  2. First Department of Medicine, Osaka University Hospital, Fukushima-Ju Osaka 553, Japan

    T. Morishima

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  1. Departments of Physiology and Medicine and Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada

    Mladen Vranic  & George Steiner  & 

  2. Department of Medicine and Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada

    Charles H. Hollenberg

  3. Division of Endocrinology and Metabolism, Toronto General Hospital, Toronto, Canada

    George Steiner

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Radziuk, J., Morishima, T. (1985). New Methods for the Analysis of Insulin Kinetics in Vivo: Insulin Secretion, Degradation, Systemic Dynamics and Hepatic Extraction. In: Vranic, M., Hollenberg, C.H., Steiner, G. (eds) Comparison of Type I and Type II Diabetes. Advances in Experimental Medicine and Biology, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1850-8_14

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  • DOI: https://doi.org/10.1007/978-1-4757-1850-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1852-2

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