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Energy Metabolism in Feasting and Fasting

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Hormones and Energy Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 111))

Abstract

The history of humans is, in large part, a chronicle of their quest for food. Humans can feast when food is available and fast during caloric deprivation without serious consequences. The capability of humans to survive marked extremes in caloric intake depends on the ability (1) to selectively oxidize and excrete certain nitrogenous metabolites, (2) to store carbohydrate and lipid metabolites in an economical form during caloric excess, and (3) to spare protein and to selectively mobilize and oxidize substrates derived from fat stores during caloric deprivation.

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References

  • Adibi, S.A. (1976). Metabolism of branched-chain amino acids in altered nutrition. Metabolism 25: 1287–1302.

    Article  PubMed  CAS  Google Scholar 

  • Ahmed, M., Gannon, M.C., and Nuttall, F.Q. (1976). Postprandial plasma glucose, insulin, glucagon and triglyceride responses to a standard diet in normal subjects. Diabetologia 12: 61–67.

    Article  PubMed  CAS  Google Scholar 

  • Balasse, E.O. and Havel, R.J. (1971). Evidence for an effect of insulin on the peripheral utilization of ketone bodies in dogs. J. Clin. Invest. 50: 801–813.

    CAS  Google Scholar 

  • Barter, P.J., Nestel, P.J., and Carroll, K.F. (1972). Precursors of plasma triglyceride fatty acid in humans. Effects of glucose consumption, clofibrate administration, and alcoholic fatty liver. Metabolism 21: 117–124.

    Article  PubMed  CAS  Google Scholar 

  • Beatty, C.H., Peterson, R.D., Bocek, R.M., and West, E.S. (1959).

    Google Scholar 

  • Acetoacetate and glucose uptake by diaphragm and skeletal muscle from control and diabetic rats. J. BioZ. Chem. 234: 11–15.

    Google Scholar 

  • Benedict, F.G. (1915). A study of prolonged fasting. Carnegie Institute of Washington, Washington, DC, publication 203.

    Google Scholar 

  • Blackburn, G.L., Flatt, J.P., Clowes, G.H.A. Jr., O’Donell, T.F., and Hensle, T.E. (1973). Protein sparing therapy during periods of starvation with sepsis or trauma. Annals of Surgery 177: 588–594.

    Article  PubMed  CAS  Google Scholar 

  • Boberg, J., Carlson, L.A., Freyschuss, U., Lassers, B.W., and Wahlquist, M.L. (1972). Splanchnic secretion rates of plasma triglycerides and total and splanchnic turnover of plasma free fatty acids in men with normo-and hypertriglyceridaemia. Eur. J. Clin. Invest. 2: 454–466.

    CAS  Google Scholar 

  • Buse, M.G., Biggers, J.F., Friderici, K.H., and Buse, J.F. (1972). Oxidation of branched chain amino acids by isolated hearts and diaphragms of the rat. J. Biol. Chem. 247: 8085–8096.

    CAS  Google Scholar 

  • Cahill, G.F. Jr., Herrera, M.G., Morgan, A.P., Soeldner, J.S., Steinke, J., Levy, P.L., Reichard, G.A. Jr., and Kipnis, D.M. (1966). Hormone-fuel interrelationships during fasting. J. Clin. Invest. 45: 1751–1769.

    Article  CAS  Google Scholar 

  • Drenick, E.J., Alvarez, L.C., Tamasi, G.C., and Brickman, A.S. (1972). Resistance to symptomatic insulin reactions after fasting. J. Clin. Invest. 51: 2757–2762.

    Article  CAS  Google Scholar 

  • Dubois, E.F. (1921). The basal metabolism in fever. JAMA 77:352357. Felig, P. (1973). The glucose-alanine cycle. Metabolism 22:179–9n7

    Google Scholar 

  • Felig, P., Owen, O.E., Wahren, J., and Cahill, G.F. Jr. (1969). Amino acid metabolism during prolonged starvation. J. CZin. Invest. 48: 584–594.

    CAS  Google Scholar 

  • Felig, P., Wahren, J., and Hendler, R. (1975). Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes 24: 468–475.

    Article  PubMed  CAS  Google Scholar 

  • Gammeltoft, A. (1950). The significance of ketone bodies in fat metabolism. I. Concentration of ketone bodies in the arterial and venous blood in human subjects during starvation. Acta Physiol. Scand. 19: 270–287.

    Google Scholar 

  • Garber, A.J., Menzel, P.H., Boden, G., and Owen, O.E. (1974). Hepatic ketogenesis and gluconeogenesis in humans. J. CZin. Invest. 54: 981–989.

    CAS  Google Scholar 

  • Goldman, R.F., Haisman, M.F., Bynum, G., Horton, E.S., and Sims, E.A.H. (1973). Experimental obesity in man: Metabolic rate in relation to dietary intake. pp. 165–186.

    Google Scholar 

  • G.A. Bray (Ed.) Obesity in Perspective. Fogarty International Center Series on Preventive Medicine, DHEW Publication No. (NIH) 75–708.

    Google Scholar 

  • Gottstein, U., Muller, W., Berghoff, W., Gartner, H., and Held, K. (1971). Zur Utilisation von nicht-veresterten Fettsauren and Ketonkorpern im Gehirn des Menschen. Klin. Wchr. 49: 406–411.

    Google Scholar 

  • Hagenfeldt, L. and Wahren, J. (1971). Human forearm muscle metabolism during exercise. VI. Substrate utilization in prolonged fasting. Scand. J. Clin. Lab. Invest. 27: 299–306.

    Article  CAS  Google Scholar 

  • Havel, R.J. (1972). Caloric homeostasis and disorders of fuel transport. N. Eng. J. Med. 287: 1186–1192.

    CAS  Google Scholar 

  • Havel, R.J., Kane, J.P., Balasse, E.O., Segel, N., and Basso, L.V. (1970). Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J. Clin. Invest. 49: 2017–2035.

    CAS  Google Scholar 

  • Hawkins, R.A., Williamson, D.H., and Krebs, H.A. (1971). Ketonebody utilization by adult and suckling rat brain in vivo. Biochem. J. 122: 13–18.

    Google Scholar 

  • Issekutz, B. Jr., Paul, P., Miller, H.I., and Bortz, W. (1968). Oxidation of plasma free fatty acids in lean and obese humans. Metabolism 17: 62–73.

    Article  PubMed  CAS  Google Scholar 

  • Keys, A.., Anderson, J.T., and Brozek, J. (1955). Weight gain from simple overeating. Metabolism 4: 427–432.

    PubMed  CAS  Google Scholar 

  • Krebs, H.A. (1972). Some aspects of the regulation of fuel supply in omnivorous animals. Adv. Enzyme Regul. 10: 397–420.

    Google Scholar 

  • Little, J.R. and Spitzer, J.J. (1971). Uptake of ketone bodies by dog kidney in vivo. Am. J. Physiol. 221: 679–683.

    CAS  Google Scholar 

  • Marliss, E.B., Aoki, T.T., Pozefsky, T., Most, A.S., and Cahill, G.F. (1971). Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man. J. CZin. Invest. 50: 814–817.

    CAS  Google Scholar 

  • Müller, W.A., Faloona, G.R., Aguilar-Parada, E., and Unger, R.H. (1970). Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N. Eng. J. Med. 283: 109–115.

    Google Scholar 

  • Nilsson, L.H. (1973). Liver glycogen content in man in the postabsorptive state. Scand. J. Clin. Lab. Invest. 32: 317–323.

    Article  CAS  Google Scholar 

  • Nilsson, L.H. and Hultman, E. (1974). Liver and muscle glycogen in man after glucose and fructose infusion. Scand. J. Clin. Invest. 33: 5–10.

    Article  CAS  Google Scholar 

  • Owen, 0.E., Block, B.S.B., Patel, M., Boden, G., McDonough, M., Kreulen, T., Shuman, C.R., and Reichard, G.A. Jr. (1977). Human splanchnic metabolism during diabetic ketoacidosis. Metabolism 26: 381–398.

    Article  Google Scholar 

  • Owen, O.E. and Cahill, G.F. Jr. (1973). Metabolic effects of exogenous glucocorticoids in fasted man. J. Clin. Invest. 52: 2596–2605.

    CAS  Google Scholar 

  • Owen, O.E., Felig, P., Morgan, A.P., Wahren, J., and Cahill, G.F. Jr. (1969). Liver and kidney metabolism during prolonged starvation. J. Clin. Invest. 48: 574–583.

    CAS  Google Scholar 

  • Owen, O.E., Morgan, A.P., Kemp, H.G., Sullivan, J.M., Herrera, M.G., and Cahill, G.F. Jr. (1967). Brain metabolism during fasting. J. Clin. Invest. 46: 1589–1595.

    Article  CAS  Google Scholar 

  • Owen, O.E., Patel, M.S., Block, B.S.B., Kreulen, T.H., Reichle, F.A., and Mozzoli, M.A. (1976). Gluconeogenesis in normal, cirrhotic and diabetic humans. In R.W. Hanson and M.A. Mehlman (Eds.) Gluconeogenesis: Regulation in Mananalian Species. John Wiley, New York.

    Google Scholar 

  • Owen, O.E. and Reichard, G.A. Jr. (1975). Ketone body metabolism in normal, obese and diabetic subjects. Israel J. Med. Sci. 11: 560–570.

    CAS  Google Scholar 

  • Owen, O.E. and Reichard, G.A. Jr. (1971). Human forearm metabolism during prolonged starvation. J. Clin. Invest. 50:15361545.

    Google Scholar 

  • Owen, O.E., Reichard, G.A. Jr., Markus, H., Boden, G., Mozzoli, M.A., and Shuman, C.R. (1973). Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses. J. Clin. Invest. 52: 2606–2615.

    CAS  Google Scholar 

  • Passmore, R. and Swindells, Y.E. (1963). Observations on the respiratory quotients and weight gains of man after eating large quantities of carbohydrate. Brit. J. Nutr. 17: 331–339.

    CAS  Google Scholar 

  • Patel, M.S., Owen, O.E., Goldman, L.I., and Hanson, R.W. (1975). Fatty acid synthesis by human adipose tissue. Metabolism 24: 161–173.

    Article  PubMed  CAS  Google Scholar 

  • Reichard, G.A. Jr., Owen, O.E., Haff, A.C., Paul, P., and Bortz, W.M. (1974). Ketone-body production and oxidation in fasting. J. Clin. Invest. 53: 508–515.

    Article  CAS  Google Scholar 

  • Reidenberg, M.M., Haag, B.L., Channick, B.J., Shuman, C.R., and Wilson, T.G.G. (1966). The response of bone to metabolic acidosis in man. Metabolism 15: 236–241.

    Article  PubMed  CAS  Google Scholar 

  • Ruderman, N.B. and Goodman, M.N. (1974). Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis. Am. J. Physiol. 226: 136–143.

    CAS  Google Scholar 

  • Ruderman, N.S. and Goodman, M.N. (1973). Regulation of ketone body metabolism in skeletal muscle. Am. J. Physiol. 224:13911397.

    Google Scholar 

  • Sapir, D.G. and Owen, O.E. (1975). Renal conservation of ketone bodies during starvation. Metabolism 24: 23–33.

    Article  PubMed  CAS  Google Scholar 

  • Sapir, D.G., Owen, O.E., Pozefsky, T., and Walser, M. (1974). Nitrogen sparing induced by a mixture of essential amino acids given chiefly as their ketoanalogues during prolonged starvation in obese subjects. J. Clin. Invest. 54: 974–980.

    CAS  Google Scholar 

  • Sherlock, S. (1975). Anatomy of the liver. p. 1. In S. Sherlock (Ed.) Diseases of the Liver and Biliary System, 5th ed. Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Sherwin, R.S., Hendler, R.G., and Felig, P. (1975). Effect of ketone infusions on amino acid and nitrogen metabolism in man. J. Clin. Invest. 55: 1382–1390.

    CAS  Google Scholar 

  • Smith, R., Fuller, D.J., Wedge, J.H., Williamson, D.H., and Alberti, K.G.G.M. (1975). Initial effect of injury on ketone bodies and other blood metabolites. Lancet I: 1–3.

    Article  Google Scholar 

  • Wahren, J., Felig, P., Cerasi, E., and Luft, R. (1972). Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J. Clin. Invest. 51: 1870–1878.

    CAS  Google Scholar 

  • Wahren, J., Felig, P., and Hagenfeldt, L. (1976). Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J. Clin. Invest. 57: 987–999.

    CAS  Google Scholar 

  • Wilmore, D.W. and Dudrick, S.J. (1968). Growth and development. of an infant receiving all nutrients exclusively by vein. JAMA 203: 140–144.

    Article  Google Scholar 

Addendum

  • Sims, E.A.H. (1976). Experimental obesity, dietaryinduced thermogenesis, and their clinical implications. Clinics Endocrinol. Metab. 5: 377–395.

    Google Scholar 

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Authors and Affiliations

  1. Temple University Health Sciences Center, 3401 N. Broad Street, Philadelphia, PA, 19140, USA

    O. E. Owen, G. A. Reichard Jr., M. S. Patel & G. Boden

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  1. O. E. Owen
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  2. G. A. Reichard Jr.
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  3. M. S. Patel
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  4. G. Boden
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Editor information

Editors and Affiliations

  1. University of Missouri-Columbia, USA

    David M. Klachko M.D. (Associate Professor of Medicine), Ralph R. Anderson Ph.D. (Associate Professor of Dairy Husbandry) & Murray Heimberg M.D., Ph.D. (Professor and Chairman of Pharmacology, Professor of Medicine) (Associate Professor of Medicine),  (Associate Professor of Dairy Husbandry) &  (Professor and Chairman of Pharmacology, Professor of Medicine)

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Owen, O.E., Reichard, G.A., Patel, M.S., Boden, G. (1979). Energy Metabolism in Feasting and Fasting. In: Klachko, D.M., Anderson, R.R., Heimberg, M. (eds) Hormones and Energy Metabolism. Advances in Experimental Medicine and Biology, vol 111. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0734-2_8

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  • DOI: https://doi.org/10.1007/978-1-4757-0734-2_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0736-6

  • Online ISBN: 978-1-4757-0734-2

  • eBook Packages: Springer Book Archive

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