Abstract
The identification of the neurobiological concomitants of ethanol dependence and withdrawal would not only provide a better understanding of the basic nature of such phenomena, but would also facilitate the development of techniques of detection, prevention, and treatment of alcoholic disease and its psychobiological consequences.
Supported by the Veterans Administration (MRIS 9183) and PHS Grants AA00200 and MH10320
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Branchey, M., Rauscher, G., and Kissin, B. Modifications in the response to alcohol following the establishment of physical dependence. Psychopharmacologia (Berl.), 22: 314–322, 1971.
Ellis, F. W., and Pick, J. R. Dose-and time-dependent relationships in ethanol-induced withdrawal reactions. Fed. Proc., 30: 568, 1971.
Falk, J. L., Samson, H. H., and Winger, G. Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science, 177: 811–813, 1972.
Falk, J. L., Samson, H. H., and Tang, M. Chronic ingestion techniques for the production of physical dependence of ethanol. In M. M. Gross (Ed.) Alcohol Intoxication and Withdrawal: Experimental Studies I pp. 197–212. New York, Plenum Press, 1973.
Freund, G. Exchangeable injection port cartridge for gas chromatographic determination of volatile substances in aqueous fluids. Anal. Chem., 39: 545–546, 1967.
Freund, G. Alcohol withdrawal syndrome in mice. Arch. Neurol., 21: 315–320, 1969.
Freund, G. Alcohol consumption and its circadian distribution in mice. J. Nutr., 100: 30–36, 1970.
Freund, G. Alcohol, barbiturate, and bromide withdrawal syndrome in mice. Ann. N. Y. Acad. Sci., 215: 224–234, 1973.
Freund, G., and Walker, D.W. Impairment of avoidance learning by prolonged ethanol consumption in mice. J. Pharmacol. Exp. Ther., 179: 284–292, 1971.
Goldstein, D. B. Relationship of alcohol dose to intensity of withdrawal signs in mice. J. Pharmacol. Exp. Ther., 180: 203–215, 1972a.
Goldstein, D. B. An animal model for testing effects of drugs on alcohol withdrawal reactions. J. Pharmacol. Exp. Ther., 183: 14–22, 1972b.
Hunt, W. A., and Majchrowicz, E. Turnover rates and steady-state levels of brain serotonin in alcohol-dependent rats. Brain Research, 72: 181–184, 1974.
Hunter, B. E., Boast, C. A., Walker, D. W., and Zornetzer, S. F. Alcohol withdrawal syndrome in rats: Neural and behavioral correlates. Pharmac. Biochem. Behay., 1: 719–725, 1973.
Hunter, B. E., Walker, D. W., and Riley, J. N. Dissociation between physical dependence and volitional ethanol consumption: Role of multiple withdrawal episodes. Pharmac. Biochem. Behay., 1974. (in press)
Kalant, H., LeBlanc, A. E., and Gibbins, R. J. Tolerance to and dependence on, ethanol. In Y. Israel and J. Mardones (Eds.) Biological Basis of Alcoholism pp. 235–269. New York, Wiley-Interscience, 1971.
Lieber, C. S., and DeCarli, L. M. Ethanol dependence and tolerance: A nutritionally controlled experiment model in the rat. Res. Commun. Chem. Pathol. Pharmacol., 6: 983–991, 1973.
Littleton, J. M., Griffiths, P. J., and Ortiz, A. The induction of ethanol dependence and the ethanol withdrawal syndrome. J. Pharm. Pharmacol. 26: 81–91, 1974.
Mello, N. K. A review of methods to induce alcohol addiction in animals. Pharmac. Biochem. Behay., 1: 89–101, 1973.
Ogata, H., Ogata, F., Mendelson, J. H., and Mello, N. K. A comparison of techniques to induce alcohol dependence and tolerance in the mouse. J. Pharmac. Exp. Ther., 180: 216–230, 1972.
Pohorecky, L. A. Effects of ethanol on central and peripheral noradrenergic neurons. J. Pharmacol. Exp. Ther., 189: 380–391, 1974.
Pohorecky, L. A., Jaffe, L. S., and Berkeley, H. A. Effects of ethanol on serotonergic neurons in the rat brain. Res. Commun. Chem. Pathol. Pharmacol., 8: 1–11, 1974.
Seevers, J. H., and Deneau, G. A. Physiological aspects of tolerance and physical dependence. In W. S. Root and F. G. Hoffmann (Eds.) Physiological Pharmacology pp. 565–640. New York, Academic Press, 1963.
Walker, D. W., and Freund, G. Impairment of shuttlebox avoidance learning following prolonged alcohol consumption in rats. Physiol. Behay., 7: 773–778, 1971.
Walker, D. W., and Zornetzer, S. F. Alcohol withdrawal in mice: Electroencephalographic and behavioral correlates. Electroencephalogr. Clin. Neurophysiol., 36: 233–243, 1974.
Wallgren, H. Neurochemical aspects of tolerance to and dependence on ethanol. In M. M. Gross (Ed.) Alcohol Intoxication and Withdrawal: Experimental Studies pp. 15–32. New York, Plenum Press, 1973.
Wallgren, H., and Barry, H., III. Actions of alcohol. New York: Elsevier, 1970.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer Science+Business Media New York
About this chapter
Cite this chapter
Walker, D.W., Hunter, B.E., Riley, J. (1975). A Behavioral and Electrophysiological Analysis of Ethanol Dependence in the Rat. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal. Advances in Experimental Medicine and Biology, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0632-1_25
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0632-1_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0634-5
Online ISBN: 978-1-4757-0632-1
eBook Packages: Springer Book Archive