Abstract
Mast cells have been isolated from the intestine (IMC) of rats previously infected with the nematode, Nippostrongylus brasiliensis. Functional studies on IMC have shown that they are responsive to antigen and possess surface IgE but, in contrast to peritoneal mast cells (PMC), IMC are unresponsive to the basic secretatogues, 48/80 and bee venom peptide 401, and hyporesponsive to ionophores. Furthermore, sodium cromoglycate, AH9679 and theorphylline inhibited secretion by PMC but not IMC, whereas doxantrazole inhibited secretion by both cells. Histochemical investigations established that there is mast cell heterogeneity in the human intestine as well as in the rat. Since GALT and BALT are important in intestinal mastocytosis it is important to determine whether the distinct functional properties of IMC reflect a distinct precursor population, inducer cell, or other factors in GALT or BALT.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M.A. Kaliner. J. Allergy and Clin. Immunol. 66:1 (1980).
L. Enerback. Acta Path. Microbiol. Scand. 66:289 (1966).
L. Enerback. Acta Path. Microbiol. Scand. 66:303 (1966).
L. Enerback. Acta Path. Microbiol. Scand. 66:313 (1966).
H.R.P. Miller and R. Walshaw. Am. J. Path. 69:195 (1972).
L. Enerback, and P.M. Lundin. Cell Tiss. Res. 150:95 (1974).
G. Mayrhofer, H. Bazin, and J.L. Gowans. Eur. J. Immunol. 6:545 (1976).
J. Tas, and R.G. Berndsen. J. Histochem. Cytochem. 25:1058 (1977).
A.D. Befus, F.L. Pearce, J. Gauldie, P. Horsewood, R.L. Goodacre, F. Cole, R.V. Heatley, and J. Bienenstock, in: “The Mast Cell — its role in health and disease,” J. Pepys and A.M. Edwards, eds., Pitman Medical Publishing Co., Ltd. (1979).
E.J. Ruitenberg, and A. Elgersma. Nature 264–258 (1976).
A.D. Befus, and J. Bienenstock. Immunology 38:95 (1979).
Y. Nawa, and H.R.P. Miller. Cell. Immunol. 42:225 (1979).
J. Denburg, A.D. Befus, and J. Bienenstock. Immunology 41:195 (1980).
A.D. Befus, M. McDermott, S. Mirski, and J. Bienenstock, in: “The Mucosal Immune System in Health and Disease,” Proc. 81st Ross Conf. Ped. Res., Ross Laboratories: Columbus, Ohio (1981).
D. Guy-Grand, and P. Vassalli. (1981) in press.
P.W. Askenase. Springer Semin. Immunopathol. 2:417 (1980).
J. Pepys, and A.M. Edwards, in: “The Mast Cell — its role in health and disease,” Pitman Medical Publishing Co., Ltd. London (1979).
O. Kawanami, V.J. Ferrans, J.D. Fulmer, and R.G. Crystal. Lab. Invest. 40:717 (1979).
S. Strobel, H.R.P. Miller, and A. Ferguson. J. Clin. Path. (1981) in press.
A.D. Befus, F.L. Pearce, J. Gauldie, P. Horsewood, and J. Bienenstock. Submitted.
F.L. Pearce, A.D. Befus, J. Gauldie, and J. Bienenstock. Submitted.
G. Atkinson, M. Ennis, and F.L. Pearce. Br. J. Pharmac. 65: 395 (1979).
S. Lange, H. Nygren, A.-M. Svennerholm, and J. Holmgren. Infect. Immun. 28:17 (1980).
P.A. Shore, A. Burkhalter, and V.H. Cohn Jr. J. Pharmacol. Exp. Immunol. 127:182 (1959).
R. Keller. Clin. Exp. Immunol. 13:139 (1973).
R.V. Heatley, B.J. Calcraft, J. Rhodes, E. Owen, and B.K. Evans. Gut 16:559 (1975).
V. Binder, L. Elsborg, J. Greibe, C. Hendriksen, L. Høj, K. Birger Jensen, E. Dritensen, J. Rask Madsen, B. Marner, P. Riis, and L. Willumsen. Gut 22:55 (1981).
J. Bienenstock, and A.D. Befus. Immunology 41:249 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Befus, A.D., Pearce, F.L., Goodacre, R., Bienenstock, J. (1982). Unique Functional Characteristics of Mucosal Mast Cells. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_73
Download citation
DOI: https://doi.org/10.1007/978-1-4684-9066-4_73
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-9068-8
Online ISBN: 978-1-4684-9066-4
eBook Packages: Springer Book Archive