Abstract
Tumor angiogenesis is the process through which certain tumors stimulate the growth of the microvascular network in the surrounding tissue. This capillary network is remarkable in that the growth is directed towards the tumor which becomes vascularized. An important fundamental question is, what is the nature of the molecular controls responsible for the directed vascularization? As cell migration is the salient feature in neovascularization the question thus becomes, what are the molecular events that control cell migration during neovascularization? A wide variety of compounds have been shown to be inducers of angiogenesis or neovascularization in vivo. These include both tumor or tissue derived factors as well as a number of chemical factors.1,2,3,4,5,6 All of these, with the exception fo angiogenin, have been shown to also induce endothelial cell migration.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
B.R. McAuslan, W. Reilly, G.N. Hannan and G.A. Gole, Angiogenic factors and their assay: activity of formyl methionyl leucyl phenylalanine, adenosine diphosphate, heparin, copper and bovine endothelium stimulating factor, Microvasc. Res. 26:323 (1983).
J. Folkman, E. Merler, C. Abernathy and G. Williams, Isolation of a tumor factor responsible for angiogenesis, J. Exp. Med. 133:275 (1971).
R.D. Kissun, C.R. Hill, A. Garner, P. Phillips, S. Kumar and J.B. Weiss, A low molecular weight angiogenic factor in cat retina, Brit. J. Ophthal. 66:165 (1982).
M.J. Banda, D.R. Knighton, T.K. Hunt and Z. Webb, Isolation of a nonmitogenic angiogenesis factor from wound fluid, Proc. Natl. Acad. Sci. USA 79:7773 (1982).
M. Ziehe, J. Jones and P.M. Gullino, Role of prostaglandin El and copper in angiogenesis, J. Natl. Cancer Inst. 69:475 (1982).
J.W. Fett, D.J. Strydom, B.R. Lobb, E.M. Alderman, J.L. Bethune, J.F. Riordan and B.L. Vallee, Isolation and characterization of angiogenin and angiogenic protein from human carcinoma cells. Biochemistry 24:5480 (1985).
D.M. Form, B.M. Pratt and J.A. Madri, Endothelial cell proliferation during angiogenesis. Lab. Invest. 55:521 (1986).
K. Nabeshima, H. Kataoka and M. Koono, Enhanced migration of tumor cells in response to collagendegradation products and tumor cell collagenolytic activity. Invasion and Metastasisy 6:270 (1986).
B.R. McAuslan and G.A. Gole, Cellular and molecular mechanisms in angiogenesis. Trans. Ophthal. Soc. UK 100:354 (1980).
D.B. Rifkin, J.L. Gross, D. Moscatelli and E. Jaffe, Proteases, angiogenesis and invasion, Symp. Fundam. Cancer Res. 36:187 (1983).
J.H. Greenberg, S. Seppa, H. Seppa and A.T. Hewitt, Role of collagen and fibronectin in neural crest cell adhesion and migration, Devel. Biol. 87:259 (1981).
I.M. Herman, Extracellular matrix-cytoskeletal interactions in vascular cells. Tissue and Cell 19:1 (1987).
D. Gospodarowicz and C.R. Ill, Extracellular matrix and control of proliferation of vascular endothelial cells, J. Clin, Invest. 65:1351 (1980).
J.A. Madri and K.S. Stenn, Aortic endothelial cell migration. I. Matrix requirements and composition, Am. J. Pathol. 106:180 (1982).
E.G. Bade and G. Nitzgen, Extracellular matrix (ECM) modulates the EGF induced migration of liver cells in serum free, hormone supplemented medium. In Vitro 21:245 (1985).
B.R. McAuslan and W. Reilly, Endothelial cell phagokinesis in response to specific metal ions, Exp. Cell Res. 130:147 (1980).
G.N. Hannan, J.W. Redman and B.R. McAuslan, Similarity of carbohydrate moieties of fibronectin derived from blood plasma and synthesized by cultured endothelial cells, Biochim. Biophys. Acta 801:396 (1984).
J. Koch, T. Fifis, V. Bender and B.A. Moss, Molecular species of epidermal growth factor carrying immuno-suppressive activity, J. Cell Biochem. 25:45 (1984).
B.R. McAuslan and H. Hoffman, Endothelium stimulating factor from Walker carcinoma cells: relation to tumor angiogenic factor, Exp. Cell Res. 119:181 (1979).
B.R. McAuslan, W. Reilly, G.N. Hannan, K. Schindhelm, B. Milthorpe and B.A. Saur, Induction or endothelial cell migration by proine analogues and its relevance to angiogenesis, Exp. Cell Res. in press (1988).
B.R. McAuslan, V. Bender, W. Reilly and B.A. Moss, New functions of epidermal growth factor: stimulation of capillary endothelial cell migration and matrix dependent proliferation. Cell Biol. Int. Reps. 9:175 (1985).
R.G. Azizkhan, J.C. Azizkhan, B.R. Zetter and J. Folkman, Mast cell heparin stimulates migration of capillary endothelial cells in vitro, J. Exp. Med. 152:931 (1980).
J.B. Weiss, C.R. Hill, R.J. Davis and B. McLaughlin, Activation of mammalian procollagenase and basement membrane — degrading enzymes by a low molecular weight angiogenesis factor. Agents and Actions, 15:107 (1984).
T. Kalebic, S. Oarbisa, B. Glaser and L.A. Liotta, Basement membrane collagen: degradation by migrating endothelial cells, Science July:283 (1983).
J.L. Gross, D. Moscatelli and D.B. Rifkin, Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro, Proc. Natl. Acad. Sci. USA, 80:2623 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Reilly, W., McAuslan, B.R. (1988). Matrix Control of Tumor Angiogenesis. In: Chien, S. (eds) Vascular Endothelium in Health and Disease. Advances in Experimental Medicine and Biology, vol 242. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8935-4_25
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8935-4_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8937-8
Online ISBN: 978-1-4684-8935-4
eBook Packages: Springer Book Archive